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Dental Gel as an Adjunct to Scaling and Root Planing for Periodontal Disease

This study is looking at whether a special dental gel, Livfresh Dental Gel (LDG), can improve the results of a common dental procedure called scaling and root planing (SRP). SRP is a deep cleaning that removes plaque and bacteria from your teeth and gums to treat periodontal disease (gum disease). You would receive SRP and then use either Livfresh Dental Gel or a standard fluoride toothpaste twice a day. The study aims to see if Livfresh Dental Gel helps reduce the depth of gum pockets more than standard toothpaste over six months. To join, you need to be between 18 and 85 years old, have at least 20 natural teeth, and show signs of gum bleeding. The current status of this study is unclear, and it plans to enroll 76 participants.

Study design
This interventional study plans to enroll 76 participants. It compares the use of Livfresh Dental Gel with standard fluoride toothpaste after a scaling and root planing procedure.
What's involved
You would undergo scaling and root planing at the start of the study. You would then brush twice daily with either Livfresh Dental Gel or a standard fluoride toothpaste between study visits for up to six months.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, reduction in gum pocket depth, will be measured from the start of the study to 6 months.

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NCT05384132

Novel Dental Gel as an Adjunct to Scaling and Root Planing

Recruiting
NAAges 18–85InterventionalTreatment
University of Alabama at Birmingham
~76 participants
Updated 2025-12-17 on ClinicalTrials.gov
What's tested:SRP + Livfresh Dental GelSRP + standard flouride dentifrice

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incremental reduction in gingival pocket depth.
Measured over From baseline to 6 months

Conditions

Periodontal Diseases
Gingival Diseases
Gingival Pocket
Gum Bleed
Plaque, Dental

Explore related trials

Periodontitis

Where it's being run

1 sites across 1 states
Alabama1

Who to contact

Maninder Kaur, BDS,MPH,MS
[email protected]
2059344506
Email the study team

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Eligibility criteria

Inclusion

Male or female subjects at least 18 years of age.
Subject must be willing and able to provide written informed consent.
Available during the course of the study.
Must have minimum of 20 natural teeth, excluding third molars.
Must have at least 20 BOP sites, excluding third molars.
Stage II or III, Grade B periodontitis with at least 4 teeth with a minimum PD of 5 mm and minimum CAL of 3mm.
No antibiotic therapy for periodontal disease or chronic use of anti-inflammatory drugs (NSAIDs) within the past month of Baseline, or during the study.
Must not have received definitive treatment (i.e., SRP or periodontal surgical therapy) for periodontitis in the last one year.
Subject must be willing and able to comply with study visits as described in the protocol.
Subjects must be available for follow up on the telephone.
Able to read and understand the consent form in English

Exclusion

• Pregnancy or breast feeding.
Medical condition that requires pre-medication prior to dental procedures.
Systemic conditions and use of medications that may affect periodontal tissues.
Severe dental disease characterized multiple decayed, untreated dental sites.
Presence of orthodontic appliances.
Diseases of oral soft or hard tissues.
Participating in another clinical trial currently or in the month preceding this study.
Stage IV and/or Grade C periodontitis.
Vertical bone defects 4mm or greater.
Subjects who have active dental infections other than periodontitis that will require dental treatment during the study period.
Excessive oral hygiene practices including use of water irrigation devices such as Waterpik or use of interdental cleansers more than twice daily.
Non-English speaking
Smokers, uncontrolled or brittle diabetics, HIV/AIDS, and subjects with severe systemic disease, e.g., cancer, lupus, pemphigus vulgaris/pemphigoid, or other oral mucous membrane diseases that would interfere with performance of oral hygiene, e.g., erosive lichen planus, recurrent major aphthous lesions, etc.
History of allergic reaction to any ingredient in the test/control dentifrices.
Presence of any condition, abnormality, or situation at Baseline that in the opinion of the Principal Investigator may preclude the subject's ability to comply with study requirements, including completion of the study or the quality of the data.
Subjects unwilling to use manual toothbrush during the study.

What this trial measures

  • Incremental reduction in gingival pocket depth.From baseline to 6 months

    Incremental reduction in PD compared to the active control at Day 180 for those sites with PD \> 4 mm as compared to control.