Preventing C. difficile in High-Risk Hospital Patients

This study is looking at ways to prevent Clostridioides difficile (C. difficile) infections in hospital patients. C. difficile is a common germ that can cause serious illness. Researchers want to see if a special "preemptive prevention bundle" can reduce the risk of infection in patients who already carry the C. difficile germ but don't have symptoms. These patients are identified through routine testing for another germ called vancomycin-resistant enterococcus (VRE). You might be able to join if you are an adult admitted to an ICU or Oncology unit and are found to carry C. difficile. The study will compare this special prevention bundle to the standard care patients usually receive, and will track infection rates for 24 months. The current status of this study is unclear.

Study design
This interventional study aims to enroll 300 participants. It compares a special prevention bundle to routine care for C. difficile.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 24 months to measure the risk of C. difficile infection.

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NCT05389904

Pre-emptive Prevention for Patients at High Risk for Hospital-onset Clostridioides Difficile

Recruiting
NAAges 18+InterventionalPrevention
Brigham and Women's Hospital
~300 participants
Updated 2026-03-04 on ClinicalTrials.gov
What's tested:Arm 1: Routine careArm 2: Preemptive C. difficile infection prevention bundle

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Risk of C. difficile infection among patients colonized with C. difficile comparing the intervention to the control group
Measured over 24 months
C. Difficile
1 sites across 1 states
Massachusetts1
  • Meghan A Baker, MD, SCD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

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Eligibility criteria

Inclusion

Patients admitted to ICU or Oncology units and identified to carry C. Difficile via VRE swab

Exclusion

Patients not identified as carriers of C. difficile and patients not admitted to ICU or oncology units
  • Risk of C. difficile infection among patients colonized with C. difficile comparing the intervention to the control group24 months

    Incidence rate ratio of CDI in colonized patients who received the intervention bundle versus who did not receive the intervention bundle