Atezolizumab and Tiragolumab for High-Risk Bladder Cancer Before Surgery

This study is looking at whether a combination of two drugs, atezolizumab and tiragolumab, can help people with high-risk urothelial carcinoma (a type of bladder cancer) that cannot be treated with cisplatin chemotherapy. These drugs are given by vein (IV) before surgery to remove the bladder and tumor. The study aims to see how long patients live without their cancer returning (relapse-free survival) and how long they live overall (overall survival), both measured for about one year after the study starts. You may be able to join if you are over 18, have muscle-invasive urothelial cancer, and meet other specific health requirements. The study is currently unclear about its recruitment status and plans to enroll 10 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 10 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for relapse-free survival and overall survival through study completion, an average of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05394337

Neoadjuvant PD-1 Plus TIGIT Blockade in Patients With Cisplatin-Ineligible Operable High-Risk Urothelial Carcinoma

Recruiting
PHASE1Ages 18+InterventionalTreatment
M.D. Anderson Cancer Center
~10 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:AtezolizumabTiragolumab

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To evaluate relapse-free survival (RFS)
Measured over Through study completion, an average of 1 year
+1 more outcome measured
Metastatic Malignancy
1 sites across 1 states
Texas1
  • Padmanee Sharma, MD, PhD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

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  • To evaluate relapse-free survival (RFS)Through study completion, an average of 1 year
  • To evaluate overall survival (OS).Through study completion, an average of 1 year