Study for Improving Learning and Memory in Mild Cognitive Impairment

This study is looking at whether memory retraining exercises can help people with Mild Cognitive Impairment (MCI) improve their new learning and memory. MCI is a condition where people have some memory or thinking problems, but they can still do their daily activities. You might be able to join if you are 60 or older, speak English fluently, and have a research-based diagnosis of Amnestic Mild Cognitive Impairment. We'll be looking to see if these exercises improve your verbal list learning and your participation in everyday life. The study aims to enroll 120 participants, but its current status is unclear.

Study design
This is a double-blind, placebo-controlled randomized clinical trial, meaning some participants will receive memory retraining exercises and others will receive placebo control memory exercises, without knowing which they are getting. The study plans to enroll 120 participants.
What's involved
You would participate in memory retraining exercises or placebo control memory exercises on a laptop computer twice a week for five weeks, totaling 10 training sessions.
Compensation
Not stated in the trial record.
Follow-up
Your verbal list learning and participation in everyday life will be measured immediately after treatment, and then again 6 and 18 months after treatment is completed.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05396248

Improve New Learning and Memory in Individuals With Mild Cognitive Impairment

Recruiting
NAAges 60+InterventionalTreatment
Kessler Foundation
~120 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:Memory Retraining ExercisesPlacebo Control Memory Exercises

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Verbal list learning
Measured over four points in time: pre-treatment, immediately following treatment, and 6- and 18- months after treatment is completed
+1 more outcome measured
Mild Cognitive Impairment

NCT05396248

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Kessler Foundation Research Center

    West Orange, New Jerseystudy coordinator listed

    Recruiting

  • University of Michigan

    Ann Arbor, Michiganstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Nancy Chiaravalloti · PRINCIPAL_INVESTIGATOR · Kessler Foundation

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

60 or older.
read and speak English fluently.
Research based diagnosis of Amnestic Mild Cognitive Impairment

Exclusion

prior stroke or neurological injury/disease (i.e. traumatic brain injury, Multiple Sclerosis, or Stroke).
history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis).
significant alcohol or drug abuse history (inpatient treatment).
Benzodiazepines and steroid use
  • Verbal list learningfour points in time: pre-treatment, immediately following treatment, and 6- and 18- months after treatment is completed

    Change in total score from Open-Trial Selective Reminding Test (OT-SRT)

  • Participation in everyday lifefour points in time: pre-treatment, immediately following treatment, and 6- and 18- months after treatment is completed

    Change in total score from Participation Assessment with Recombined Tools