A Natural History Study of Metabolic Sizing in Health and Disease

This study is looking for healthy volunteers and people with certain health conditions to help researchers understand metabolism better. Scientists want to find more accurate ways to measure how your body uses energy (metabolic rate). They believe current methods might not work for everyone. This study will examine the connections between your metabolism, body composition (what your body is made of, like fat and muscle), and body surface area. You can join if you are 2 years or older and healthy, or if you have conditions like diabetes, obesity, kidney disease, or cancer. The researchers will compare estimated body surface area to measured body surface area and see if measured body surface area helps predict your resting energy expenditure (how many calories your body burns at rest).

Study design
This is an observational study, meaning no interventions are given. It aims to enroll 2000 participants, including both healthy individuals and those with certain medical conditions.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured at "Per study visit," which suggests measurements are taken during your visits to the study site.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05398783

A Natural History Study of Metabolic Sizing in Health and Disease

Recruiting
Not specifiedAges 2–99Observational
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
~2,000 participants
Updated 2026-09-15 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Increase in R^2
Measured over Per study visit
+1 more outcome measured
Metabolic Disorders
Cancer
Chronic Kidney Disease
Diabetes
Normal Physiology

NCT05398783

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • National Institutes of Health Clinical Center

    Bethesda, Marylandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Kong Y Chen, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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Eligibility criteria

Inclusion

Male or female, aged \>=2 years
In good general health as evidenced by medical history
Male or female, aged \>=2 years
Diagnosed with diseases thought to alter metabolism or body composition (such as weight loss or gain, diabetes, renal disease, obesity, cancer, etc.) or taking medications thought to alter metabolism or body composition.

Exclusion

Participants over 200 kg due to the weight limit of the equipment.
Presence of any implanted device that would interfere with measurements.
Any moderate to severe limitations in mobility that would impede participation
Hemoglobin less than 10 g/dL (in participants who would have blood drawn for research purposes).
Participants with dietary allergies, intolerances or eating patterns that would preclude them from consuming metabolic meals.
Participants unwilling or unable to give informed consent.
Participants with any other significant physical, medical, or psychiatric limitations, illness or conditions that may preclude them from completing the majority of the tests in this study per the discretion of the PI.
  • Increase in R^2Per study visit

    Increase in R2 when measured BSA is added to equations predicting REE

  • Mean difference and limits of agreement between measured and predicted BSAPer study visit

    Mean difference and limits of agreement between measured BSA and predicted BSA calculated from traditional biometrics such as height and weight