Blood Pressure Effects on Cognition and Brain Blood Flow in Parkinson's Disease
This study is looking at how blood pressure affects thinking and blood flow in the brain for people with Parkinson's disease (PD). Specifically, it's interested in orthostatic hypotension (OH), which is low blood pressure when standing up. Researchers want to understand how low blood pressure might affect your thinking abilities, even if you don't feel dizzy. You might be able to join if you have early to moderate-stage Parkinson's disease, are at least 50 years old, and can walk without help. The study will use a tilt table (a special table that can move you from lying down to standing up) and cognitive tests to see how your thinking changes in different body positions. Success will be measured by changes in your verbal fluency test scores and brain blood flow over time, up to 30 months. The current status of this study is unclear, and it plans to enroll 60 participants.
- Study design
- This is an interventional study planning to enroll 60 participants. It will involve diagnostic tests using a tilt table.
- What's involved
- You will have a 3-hour screening visit for medical history, exams, and tests, including a tilt table test. If eligible, you'll have a separate 3-hour baseline study visit, where you'll need to abstain from caffeine for 24 hours.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your verbal fluency and brain blood flow will be measured for up to 30 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Blood Pressure Effects on Cognition and Brain Blood Flow in PD
At a glance
Conditions
NCT05400174
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of California San Diego
San Diego, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Exclusion
What this trial measures
- Delis-Kaplan Executive Function System Verbal Fluency Test score (number of words per minute). Minimum: 0; Maximum: N/A; higher is betterup to 30 months
Participant says as many words in 1 minute as possible each of several letter or category prompts.
- Oxygenated and deoxygenated hemoglobin change from baselineup to 30 months
Functional near-infrared spectroscopy will measure relative changes in oxygenated and deoxygenated hemoglobin variables