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Understanding Oxygen Exposure During Mechanical Ventilation (OXY-BAL)

This observational study, called OXY-BAL, is looking at how oxygen exposure during mechanical ventilation (a machine that helps you breathe) affects certain molecules in your body. Specifically, researchers want to identify and measure oxidized lipids (fats that have reacted with oxygen) and other related substances. They are interested in how these substances change after patients receive oxygen levels above 50% for at least 1.5 hours while on a ventilator. The study aims to enroll 200 adults aged 18 to 110 who need mechanical ventilation for at least 48 hours. The main goal is to measure specific oxidized fats (n6-PUFAs and n3-PUFAs) on days 1 and 2 of mechanical ventilation to better understand how oxygen affects the lungs.

Study design
This is an observational study, meaning researchers will watch and collect information without giving new treatments. It aims to include 200 participants.
What's involved
You would need to be on mechanical ventilation in the Intensive Care Unit for at least 48 hours and receive oxygen exposure of more than 50% for 1.5 hours. Researchers will collect two small fluid samples from your lungs (mini bronchoalveolar lavage) 24 hours apart.
Compensation
Not stated in the trial record.
Follow-up
Measurements of oxidized fats will be taken on days 1 and 2 of mechanical ventilation.

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NCT05412810

Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).

Recruiting
Not specifiedAges 18+Observational
Ohio State University
~200 participants
Updated 2024-04-26 on ClinicalTrials.gov
What's tested:oxygen

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Oxidized n6-PUFAs (Poly Unsaturated Fatty Acids)
Measured over days 1, and 2
+1 more outcome measured

Conditions

Mechanical Ventilation Complication
Hyperoxia

Explore related trials

HyperoxiaMechanical Ventilation Complication

Where it's being run

1 sites across 1 states
Ohio1

Who to contact

Sarah Karow
[email protected]
6142920031
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

1.Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others
2)Chronic respiratory failure prior to admission;
3)Hemoptysis or diffuse alveolar hemorrhage
4)Medication use such as N acetyl cysteine; aspirin, fish oil supplements.
5)Primary team prohibits bronchoscopy for a specific clinical indication or safety;

What this trial measures

  • Oxidized n6-PUFAs (Poly Unsaturated Fatty Acids)days 1, and 2

    Polyunsaturated fatty acids will be measured by mass spectrometry and compared in patients with optimized vs liberal oxygenation with moderated t tests

  • Oxidized n3-PUFAs (Poly Unsaturated Fatty Acids)days 1, and 2 of mechanical ventilation

    Polyunsaturated fatty acids will be measured by mass spectrometry and compared in patients with optimized vs liberal oxygenation with moderated t tests