Observational Study of the Ocular Microbiome

This study is looking at the tiny living organisms (microbiome) that naturally live on the surface of your eyes. Researchers want to understand what a healthy eye microbiome looks like and how it might be connected to different eye conditions, like glaucoma. If you join, you'll have a simple swab taken from under your eyelids. The study is open to adults aged 18 and older, including those with normal eyes, or mild glaucoma that is well-controlled. The main goal is to understand what a normal eye microbiome is after three years of observation. This is an observational study, meaning you won't receive any new treatments, but researchers will gather information about your eye health and the microbes present.

Study design
This is an observational study planning to enroll 500 participants. It is designed to look at groups of people over time.
What's involved
You would have a simple eye swab taken from under the eyelids of both eyes. The study aims to measure the normal ocular microbiome at 3 years.
Compensation
Not stated in the trial record.
Follow-up
The normal ocular microbiome will be measured at 3 years.

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NCT05414994

Assessment of the Ocular Microbiome in Health and Disease

Recruiting
Not specifiedAges 18+Observational
Vanderbilt University Medical Center
~500 participants
Updated 2026-01-22 on ClinicalTrials.gov
What's tested:Eye swab

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Normal Ocular Microbiome
Measured over 3 years
Microbial Colonization
Eye Diseases
Ophthalmopathy
1 sites across 1 states
Tennessee1

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Eligibility criteria

Inclusion

18 years of age or older
Provide informed consent
Cohort A - normal eyes with no ocular disease
Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
Cohort D - Dry AMD (age related macular degeneration)
Cohort E - Wet AMD
Cohort F - diabetic retinopathy

Exclusion

Prior ocular disease either of the anterior or posterior segment
Any medical comorbidities except well controlled DH and HTN
Unable to follow up with study procedures as described
  • Normal Ocular Microbiome3 years

    Number of patients in middle Tennessee with a normal ocular microbiome by development of a normative database.