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Inhaled Isopropyl Alcohol for Nausea in Children

This study is looking at whether inhaled isopropyl alcohol can help children aged 7 to 17 who are experiencing nausea or vomiting. Researchers want to see if it works better than or as well as oral ondansetron (a common anti-nausea medication) or a placebo (normal saline pad). You could be eligible if you have significant nausea or vomiting and weigh at least 15 kg. The study will measure changes in your nausea score at 10 minutes, 30 minutes, and when you are discharged from the emergency department. The current status of this study is unclear, and it plans to enroll 84 children.

Study design
This is an interventional study that will randomly assign participants to one of three groups: inhaled isopropyl alcohol, oral ondansetron, or inhaled placebo. It plans to enroll 84 participants.
What's involved
After consenting, you will be randomized to receive one of the three interventions. Your nausea will be assessed at different time points.
Compensation
Not stated in the trial record.
Follow-up
Your nausea score will be measured at 10 minutes, 30 minutes, and at emergency department discharge (up to 10 hours) after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05418244

Inhaled Isopropyl Alcohol for Treatment of Nausea

Recruiting
PHASE2Ages 7–17InterventionalTreatment
State University of New York at Buffalo
~84 participants
Updated 2025-10-08 on ClinicalTrials.gov
What's tested:Inhaled Isopropyl AlcoholOral OndansetronInhaled Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Nausea Score at 30 Minutes
Measured over 30 minutes post-intervention as compared to baseline
+2 more outcomes measured

Conditions

Vomiting
Nausea
Children, Only

Explore related trials

NauseaVomiting

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Alana Koehler, MD · PRINCIPAL_INVESTIGATOR · SUNY Buffalo
  • Heather Territo, MD · STUDY_DIRECTOR · SUNY Buffalo

Who to contact

Haiping Qiao, MBBS, MS
[email protected]
7163230055
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients with a chief complaint of nausea or vomiting
Ages 7-178 years, both sexes
Weight ≥ 15 kg
Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10

Exclusion

1\. Require IV access
Inability to breathe in/out through the nose
Anosmia (self- or parental report)
Allergy to isopropyl alcohol or ondansetron
Current or history of alcohol abuse
Inability to communicate feeling nauseous
Inability to follow directions regarding taking deep breaths through the nose
Known prolonged QT interval
Pregnancy
Received antiemetics within the last 8 hours
Currently taking apomorphine

What this trial measures

  • Change in Nausea Score at 30 Minutes30 minutes post-intervention as compared to baseline

    Baxter Animated Retching Faces nausea score, 0-10 with higher score meaning worse nausea

  • Change in Nausea Score at 10 Minutes10 minutes post-interventnon as compared to baseline

    Baxter Animated Retching Faces nausea score, 0-10 with higher score meaning worse nausea

  • Change in Nausea Score at DischargeAt ED discharge (assessed up to 10 hours) as compared to baseline

    Baxter Animated Retching Faces nausea score, 0-10 with higher score meaning worse nausea