Deep Brain Stimulation for Treatment-Resistant Depression and Epilepsy
This study is exploring how the brain processes social and emotional information in people with treatment-resistant depression and epilepsy. Researchers are using a device called Directional Deep Brain Stimulation (DBS), specifically Boston Scientific Vercise DBS leads and 16-channel implanted pulse generators (IPGs), to understand and potentially change these brain processes. You might be able to join if you are between 22 and 70 years old, have a diagnosis of major depressive disorder, and are undergoing invasive brain monitoring for epilepsy. The study aims to measure how different parts of the brain are connected and how brain activity changes with stimulation. The current status of this study is unclear.
- Study design
- This is an interventional study planning to enroll 84 participants. It involves using a medical device to understand brain activity.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary measurements for this study will be taken for up to 8 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Number of streamlines connecting between intracranial stimulation volume and recording volumes.up to 8 weeks
To characterize structural connectivity using diffusion-weighted neuroimaging, we will calculate the outcome measures of the number of streamlines connecting target points.
- Evoked potentials arising from stimulation.up to 8 weeks
To characterize short latency mono- or oligo-synaptic connections of the stimulation volumes to sEEG recording positions using the single pulse-evoked potentials (PEP) technique, the outcome measure will be the number of evoked potentials arising from applied stimulation.