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Observational Study of Extracellular Vesicles in Non-Small Cell Lung Cancer

This study is looking at fluid rinsed from your airways (bronchial washings) during surgery for non-small cell lung cancer (NSCLC). Researchers want to see if these samples contain tiny particles called extracellular vesicles (EVPs). The goal is to learn more about NSCLC and how it might come back. You could be eligible if you are 18 or older and are having surgery for primary lung cancer. The study aims to see if enough EVPs can be found in these samples to help researchers understand your cancer better. The study is currently unclear about its recruitment status.

Study design
This is an observational study, meaning researchers will collect information without giving you any new treatments. It plans to include 200 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will isolate exosomes from bronchial washings on day 1. No further follow-up is specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05424029

Extracellular Vesicles and Particles (EVP) as Biomarkers of Recurrence in Non-Small Cell Lung Cancer

Recruiting
Not specifiedAges 18+Observational
Memorial Sloan Kettering Cancer Center
~200 participants
Updated 2026-07-07 on ClinicalTrials.gov

At a glance

Recruiting sites
7 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
to isolate exosomes from bronchial washings
Measured over day 1

Conditions

Non-Small Cell Lung Cancer

Explore related trials

Lung Non-Small Cell Carcinoma

Where it's being run

7 sites across 2 states
New York4
New Jersey3

Study leadership

  • David Jones, MD · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

Who to contact

David Jones, MD
[email protected]
212-639-6428
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

All patients ≥ 18 years of age undergoing consideration of surgical resection, including lobar resections, sublobar resections, and pneumonectomies, for primary lung cancer will be eligible.
Patients with previously resected disease and/or previous radiation therapy will be considered on a case by case basis.

Exclusion

Patients with active infection or pneumonia which may impact exosome makeup
Additionally, if at the discretion of the operating surgeon, obtaining bronchial washings would lead to undue morbidity, the patient would be excluded and replaced

What this trial measures

  • to isolate exosomes from bronchial washingsday 1

    every patient from whom the essential specimens have been acquired will be evaluated to determine if more than 100,000 microvesicles can be isolated for exosome purification