Back to search results

Observational Study of VA-ECMO for Cardiogenic Shock

This observational study is looking at how a heart-lung machine called Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) affects the heart in people experiencing cardiogenic shock (when your heart suddenly can't pump enough blood to meet your body's needs) due to acute coronary syndrome (a sudden reduction of blood flow to the heart). Researchers will measure how the heart's pumping ability changes when VA-ECMO support is at its highest and lowest levels. This study aims to understand these physiological effects. You might be able to join if you are 18-75 years old, have severe cardiogenic shock from acute coronary syndrome requiring VA-ECMO, and meet certain blood pressure and medication requirements. The study plans to enroll 200 participants. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without giving any specific intervention. It plans to include 200 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements are taken at Day 3 of ECMO.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05426083

Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

Completed
Not specifiedAges 18+Observational
University of Minnesota
~45 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:Physiological Assessment

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pressure-volume loops at the highest level of VA-ECMO support and the lowest level of VA-ECMO support.
Measured over Day 3 of ECMO

Conditions

Acute Coronary Syndrome
Cardiogenic Shock

Explore related trials

Acute Coronary SyndromeCardiogenic Shock

NCT05426083

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Minnesota

    Minneapolis, Minnesotano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Demetris Yannopoulous, MD · PRINCIPAL_INVESTIGATOR · University of Minnesota

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age 18-75 years
SCAI D/E CS requiring VA-ECMO support based on treating team's judgement.
MAP \>65 mmHg on \<3 vasopressors/inotropes at the time of consent
Cardiogenic shock due to acute coronary syndrome identified by coronary angiography at the index hospitalization per standard cardiology practice

Exclusion

VA-ECMO for sepsis, pulmonary embolism, COVID-19 related cardiorespiratory failure, severe RV failure due to severe idiopathic pulmonary hypertension
CS due to other (non-ACS) etiologies
Known patient with severe left ventricular dysfunction and stage IV NYHA heart failure being evaluated for or with a history of LVAD and transplantation prior to commencement of VA-ECMO
Profound vasoplegia with MAP \<65 mmHg on 3 vasopressors/inotropes
Moderate to severe aortic regurgitation (contraindication to VA-ECMO)
Moderate to severe aortic stenosis (contraindication to LV instrumentation with PV loop catheter)
Bleeding complications requiring ongoing transfusions of blood products
Ischemic lower extremities
Evidence of circuit thrombosis or fibrin accumulation (turndown increases risk for stroke and clot formation)
Evidence of sepsis or septic shock
Evidence of LV thrombus on echocardiography (contraindication for accessing LV cavity with catheters)

What this trial measures

  • Pressure-volume loops at the highest level of VA-ECMO support and the lowest level of VA-ECMO support.Day 3 of ECMO

    Pressure-volume loops at the highest level of VA-ECMO support and the lowest level of VA-ECMO support.