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eHealth Delivery for Cancer Genetic Testing

This study is looking at new ways to deliver genetic testing for cancer. It compares the usual way of getting genetic counseling from a genetic counselor (Standard of Care) with a new web-based program (Pre-Test Intervention and Post-Test Intervention). This program would give you your genetic test results and explain what they mean online. The study wants to see if the web-based program works as well as or better than traditional counseling in helping people understand their results, feel less worried, and take steps to reduce their cancer risk. We are looking for about 1000 adults, aged 18 or older, who speak English, have not had genetic testing before, and meet specific guidelines for genetic testing. The study is currently unclear on its recruitment status.

Study design
This study is a randomized comparison between two different ways of delivering genetic testing information. It plans to include about 1000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for about 1 year to measure their understanding, well-being, and use of genetic services.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05427240

eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer

Recruiting
NAAges 18+Interventional
Abramson Cancer Center at Penn Medicine
~1,000 participants
Updated 2026-01-16 on ClinicalTrials.gov
What's tested:Pre-Test InterventionStandard of CarePost-Test Intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The KnowGene Scale
Measured over Through study completion, an average of 1 year
+2 more outcomes measured

Conditions

Cancer

Explore related trials

Malignant Neoplasm

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Angela R Bradbury, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

Angela R Bradbury, MD
[email protected]
215 615 3341
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18 years of age or older
Speak and understand English
Male or Female
No prior germline genetic testing
Meet current National Comprehensive Cancer Network (NCCN) guidelines for germline genetic testing

Exclusion

Communication difficulties such as:
Uncorrected or uncompensated hearing and/or vision impairment
Uncorrected or uncompensated speech defects
Uncontrolled psychiatric/mental condition or severe physical, neurological or cognitive deficits rendering individual unable to understand study goals and tasks

What this trial measures

  • The KnowGene ScaleThrough study completion, an average of 1 year

    Change in Knowledge - Score Range = 0-16, Higher score = Better outcome

  • Patient Reported Outcome Measurement Information System (PROMIS)Through study completion, an average of 1 year

    Change in General Anxiety - Score Range = 4-20, Lower score = Better outcome

  • Uptake of Genetic ServicesThrough study completion, an average of 1 year

    Testing uptake per arm - Yes/No