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Preoperative Corticosteroids for Autoimmune Thyroid Disease

This study is looking at whether a short course of Dexamethasone, a corticosteroid, can reduce inflammation in your thyroid gland before surgery. You could be eligible if you have Graves' disease or Hashimoto's disease, confirmed by positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb), and are planning to have your thyroid removed. The study aims to see if Dexamethasone makes the surgery easier by measuring your Thyroid Difficulty Scale score on the day of surgery. Another group will receive a placebo (an inactive substance). The study plans to enroll 76 participants, but its current status is unclear.

Study design
This is an interventional study that plans to enroll 76 participants. You would be randomly assigned to receive either Dexamethasone or a placebo before surgery.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, Thyroid Difficulty Scale score, is measured at the Day of Surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05435547

Preoperative Corticosteroids in Autoimmune Thyroid Disease

Recruiting
PHASE4Ages 18+InterventionalTreatment
Indiana University
~76 participants
Updated 2026-08-05 on ClinicalTrials.gov
What's tested:DexamethasonePlacebo

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Thyroid difficulty Scale score
Measured over Day of Surgery

Conditions

Graves Disease
Hashimoto Disease

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NCT05435547

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • IU Health Methodist Hospital

    Indianapolis, Indianano site contact published

    Recruiting

  • IU Health North Hospital

    Indianapolis, Indianano site contact published

    Recruiting

  • IU Health University Hospital

    Indianapolis, Indianano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Alexandria McDow, MD · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

Alexandria McDow, MD
[email protected]
317-944-4377
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Exclusion

Pediatric patients \< 18
Prior treatment with RAI
Prior neck surgeries
Known diagnosis of thyroid cancer
Diabetic patients on medications
A history of adverse reactions to corticosteroids.
Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy, or a history of adverse reactions to corticosteroids.

What this trial measures

  • Thyroid difficulty Scale scoreDay of Surgery

    This scale is completed by the surgeon to assess the difficulty of a thyroid operation, and includes 4 parameters (vascularity, friability, mobility/fibrosis, and gland size). The scale ranges from 4 points (best outcome) - 20 points (worst outcome). Higher scores indicate a more difficult operation.