Patch-free Occlusion Therapy for Amblyopia

This study is looking at a new way to treat amblyopia (sometimes called "lazy eye") in children aged 3 to 12 years old. It compares two treatments: "Patch-free occlusion therapy," which uses special filters in glasses, and the usual "Adhesive patch" treatment. The goal is to see if the patch-free method works better to improve vision and if children stick with it more easily. To join, children need to have amblyopia and a specific difference in vision between their eyes. The study will measure changes in vision after 12 weeks to see which treatment is more successful. The current status of this study is unclear.

Study design
This is a randomized clinical trial involving 68 participants. Children will be randomly assigned to either the patch-free occlusion therapy or the standard adhesive patch treatment.
What's involved
Participants will use their assigned treatment at home for 12 weeks. Vision will be checked at 6 weeks and all initial tests will be repeated at 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Some participants may have the option to continue treatment and have their vision reassessed at 18 and 24 weeks.

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NCT05440448

Patch-free Occlusion Therapy

Recruiting
NAAges 3–12InterventionalTreatment
Retina Foundation of the Southwest
~68 participants
Updated 2026-01-07 on ClinicalTrials.gov
What's tested:Patch-free occlusion therapyAdhesive patch

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in amblyopic eye visual acuity measured with a logMAR visual acuity chart
Measured over 12 weeks
Amblyopia
1 sites across 1 states
Texas1

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Eligibility criteria

Inclusion

3-12 years
male and female
strabismic, anisometropic, or combined mechanism amblyopia (visual acuity: 0.3-0.8 logMAR)
interocular visual acuity difference ≥0.3 logMAR
wearing glasses (if needed) for a minimum of 8 weeks with no change in visual acuity at 2 visits ≥4 weeks apart
child's ophthalmologist and family willing to forgo standard patching treatment during the study

Exclusion

Prematurity ≥8 wk
coexisting ocular or systemic disease
developmental delay
myopia \> -3.00D
  • Change in amblyopic eye visual acuity measured with a logMAR visual acuity chart12 weeks

    change in logMAR relative to baseline