This study is looking at whether pimavanserin (Nuplazid) can help Veterans who have both post-traumatic stress disorder (PTSD) and insomnia (trouble falling or staying asleep). Pimavanserin is a medication approved for other conditions, and this study will see if it can improve sleep for Veterans with PTSD. You would receive either pimavanserin 34mg or a placebo (a pill with no medicine) once a day at bedtime for 8 weeks. The main goal is to see how your sleep quality changes, measured by the Insomnia Severity Index (ISI). This study is for adult Veterans, aged 18-64, who meet specific criteria for chronic insomnia disorder. The study is currently unclear on its recruitment status.

Study design

This is a preliminary randomized, double-blind, placebo-controlled study involving 60 participants.

What's involved

Participants will take either pimavanserin 34mg or a placebo at bedtime for 8 weeks. They will also complete sleep studies and wear actigraphy watches.

Compensation

Not stated in the trial record.

Follow-up

Your sleep quality will be measured at 8 weeks post-randomization.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.