This observational study aims to understand why some women experience recurrent pregnancy loss (RPL), which is when a woman has two or more miscarriages. Researchers want to find genetic reasons for RPL and discover genetic markers that can predict it. They will collect samples from women who have experienced pregnancy loss and their partners to look at their genes. The study is looking for 500 participants and will follow their progress for 5 years to determine the genetic causes of RPL. You may be able to join if you are a woman between 18 and 50 years old who has had a recent pregnancy loss before 20 weeks and a history of one or more prior pregnancy losses, and your current pregnancy was confirmed to be chromosomally normal.

Study design

This is an observational study aiming to recruit up to 500 participants across two cohorts to identify genetic causes of recurrent pregnancy loss.

What's involved

Participants will provide tissue from a product of conception (POC) and DNA samples (blood or saliva). Additional DNA samples from family members or prior pregnancy losses may be requested.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint to determine genetic etiology for Recurrent Pregnancy Loss will be measured at 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.