Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

{ "Imaging for Metastatic Non-Small Cell Lung Cancer with Brain Metastases", "This study is looking at a new imaging agent called fluorine-18-AlphaVBeta6-BP (\[18F\]-αvβ6-BP) to see how well it can detect non-small cell lung cancer (NSCLC) that has spread, especially to the brain. Researchers believe this new imaging method, when used with a PET/CT scan, could be a sensitive way to assess the disease. You might be able to join if you are over 18, have NSCLC with brain metastases, and are expected to live at least 3 months. The study aims to see how accurate this new imaging agent is compared to standard methods. The current status of the study is unclear, and it plans to enroll 20 participants.", "design": "This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 20 participants.", "commitments": "You would receive two injections of \[18F\]-αvβ6-BP for PET/CT scans at baseline and again 8-12 weeks later. You will also have standard-of-care imaging like FDG PET/CT and brain MRI.", "compensation": "Not stated in the trial record.", "follow_up": "The primary endpoint, comparing imaging to tissue samples, is measured up to six months." }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05452005

Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

Recruiting
PHASE1Ages 18+InterventionalDiagnostic
University of California, Davis
~20 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:[18F]-αvβ6-BP

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
[18F]-αvβ6-BP PET/CT imaging compared to immunohistochemistry
Measured over Up to six months
Lung Cancer
Lung Cancer Metastatic
Brain Metastases
Non Small Cell Lung Cancer
1 sites across 1 states
California1
  • Julie L. Sutcliffe, PhD · PRINCIPAL_INVESTIGATOR · The Regents of the University of California (Davis)

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  • [18F]-αvβ6-BP PET/CT imaging compared to immunohistochemistryUp to six months

    Standard uptake value (SUV) values from \[18F\]-αvβ6-BP PET/CT will be compared to immunohistochemistry (IHC) αvβ6 staining of archival tissue to assess the sensitivity of \[18F\]-αvβ6-BP PET/CT to detect αvβ6 positive metastasis in NSCLC