Learning and Plasticity in Macular Degeneration
This study is exploring new ways to help people with central vision impairment due to macular degeneration. Researchers are testing two types of behavioral training: "Training visual sensitivity" and "Combination training." These trainings aim to improve how your brain processes visual information and uses your remaining vision. You might be able to join if you are 18-89 years old, have severe vision impairment (20/100 or worse) in both eyes due to macular degeneration, and have specific light sensitivity in your macula (the central part of your retina). The study will measure success by looking at changes in your vision, such as how you use your eyes to look at things (saccadic precision) and how steady your gaze is (fixation stability) after about 7 weeks of training. The current status of this study is unclear, but it plans to enroll 60 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific training. It plans to enroll 60 participants, but the phase is not specified.
- What's involved
- You would participate in training blocks over approximately 7 weeks. Your vision will be measured at the beginning and within 3 weeks after training ends.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your vision will be assessed within 3 weeks after completing the approximately 7-week training period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Factors in Learning And Plasticity: Macular Degeneration
At a glance
Conditions
NCT05454124
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
UAB
Birmingham, Alabamastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Change from Baseline Radial Bias from the Crowding Task after completion of Training at approximately 7 weeksBaseline and Within 3 weeks of training completion, training is complete 7 weeks from baseline on average
The ratio of the crowding threshold along the axis connected to the fovea vs. along the orthogonal axis.
- Change from Baseline Saccadic Precision after Completion of Training at approximately 7 weeksBaseline and Within 3 weeks of training completion, training is complete 7 weeks from baseline on average
Consistency across trials in placement of the first saccade calculated by the distribution across trials (bivariate contour ellipse area) of the landing point of the first fixation of each trial.
- Change from Baseline Fixation Stability after Completion of Training at approximately 7 weeksBaseline and Within 3 weeks of training completion, training is complete 7 weeks from baseline on average
Normalizing fixations in the PRL to the first fixation to that region and calculating the distribution of all fixation locations in this normalized space (measured as a bivariate contour ellipse area).