Observational Study on Vaping and Blood Vessel Health

This study aims to understand how vaping affects your blood vessels, especially those in your lungs, and if it causes early damage. Researchers are looking for two groups of people: current electronic cigarette (EC) Puff Bar users (using 5% nicotine daily or occasionally for at least 6 months) and healthy individuals who have never smoked or vaped. Both groups should be between 18 and 40 years old. The study will measure changes in your airway blood flow reactivity (QAW), pulmonary vascular resistance (PVR - a measure of blood flow resistance in the lungs), and flow-mediated vasodilation (FMD - how well your blood vessels widen) to see if vaping has an impact. The study plans to enroll 90 participants.

Study design
This is an observational study, meaning researchers will observe participants without providing any specific interventions. It plans to enroll 90 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken up to 1 week for airway blood flow reactivity and up to 4 weeks for pulmonary vascular resistance and flow-mediated vasodilation.

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NCT05454267

Early Detection of Vaping-related Vascular Diseases

Recruiting
Not specifiedAges 18–40Observational
University of Miami
~90 participants
Updated 2026-05-15 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Airway blood flow reactivity (QAW)
Measured over Up to 1 week
+2 more outcomes measured
Vaping
Blood Vessel Injury
1 sites across 1 states
Florida1
  • Adam Wanner, MD · PRINCIPAL_INVESTIGATOR · University of Miami

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  • Airway blood flow reactivity (QAW)Up to 1 week

    QAW will be measured via soluble gas uptake method

  • Pulmonary vascular resistance (PVR)Up to 4 weeks

    PVR will be measured via echocardiography

  • Flow-mediated vasodilation (FMD)Up to 4 weeks

    FMD will be measured by blood pressure cuff deflation using ultrasound