This study is looking at how a special imaging agent, [18F]-PI-2620, can help us see tau protein buildup in the brain. Tau buildup is linked to certain brain diseases. Researchers will compare these brain scans in people with frontotemporal lobar degeneration (FTLD), people with atypical Alzheimer's disease, and people who are cognitively normal (meaning their thinking and memory are typical for their age). The goal is to see if [18F]-PI-2620 can accurately measure tau accumulation in different brain regions. You would need to be at least 18 years old and already enrolled in the UNICORN study (IRB #842873) to participate. The study aims to enroll 72 participants.

Study design

This is an interventional study planning to enroll 72 participants. It is a companion imaging study to the UNICORN observational study.

What's involved

You would undergo a single PET CT scan. You must also be concurrently enrolled in the UNICORN study, which involves periodic (typically annual) MRI and clinical/neuropsychological assessments.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoints (whole brain and regional brain SUVR) are measured once during a single PET CT scan.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.