Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
This study is looking at a non-drug treatment called transcutaneous spinal stimulation (TSS) for lower limb spasticity (muscle stiffness and spasms) in people with spinal cord injuries. Spasticity can make daily activities difficult and cause pain. TSS uses electrical neuromodulation, which involves placing electrodes on your back and abdomen to deliver electrical signals. The researchers want to see if TSS can reduce spasticity by measuring changes in your reflexes. You might be able to join if you are 18 or older, have had a spinal cord injury for more than 6 months, and experience at least mild spasticity in your legs. The study plans to enroll 12 participants, but its current status is unclear.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 12 participants.
- What's involved
- The study will involve an intervention session lasting 15-30 minutes, during which reflex measurements will be taken.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be taken before and after an intervention session (30 minutes), and before and during an intervention session (15 minutes).
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Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
At a glance
Conditions
Where it's being run
2 sites across 1 statesStudy leadership
- Matthias J Krenn, PhD · PRINCIPAL_INVESTIGATOR · University of Mississippi Medical Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in posterior root reflex amplitudeBefore and after an intervention session (30 minutes)
The amplitudes of the posterior root reflexes will be calculated and normalized to the maximum response amplitude from the recruitment curve for each muscle separately. The respective values will be averaged over all muscles and used as an outcome measure.
- Change in posterior root reflex amplitude (during intervention)Before and during an intervention session (15 minutes)
The amplitudes of the posterior root reflexes will be calculated and normalized to the maximum response amplitude from the recruitment curve for each muscle separately. The respective values will be averaged over all muscles and used as an outcome measure.
- Change in flexion withdrawal reflex root-mean-squareBefore and after an intervention session (30 minutes)
The cumulative root-mean-square values of the reflex amplitude in a window from 50 to 200 ms after the stimulation pulse over all recorded muscles.
- Change in flexion withdrawal reflex root-mean-square (during intervention)Before and during an intervention session (15 minutes)
The cumulative root-mean-square values of the reflex amplitude in a window from 50 to 200 ms after the stimulation pulse over all recorded muscles.
- Change in pendulum test indexBefore and after an intervention session (30 minutes)
The pendulum test provides the spasticity index which is calculated based on the knee angle of the initial horizontal leg position of the pendulum test, the angle at which the leg reversed for the first time from flexion to extension, and the final knee resting angle.
- Change in pendulum test index (during intervention)Before and during an intervention session (15 minutes)
The pendulum test provides the spasticity index which is calculated based on the knee angle of the initial horizontal leg position of the pendulum test, the angle at which the leg reversed for the first time from flexion to extension, and the final knee resting angle.