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Testing Adaptive Interventions for PTSD Treatment

This study is testing different ways to treat Posttraumatic Stress Disorder (PTSD) in federally qualified health centers. Researchers want to see if starting with a specific type of talk therapy, like Prolonged Exposure for Primary Care (PE-PC), Full Prolonged Exposure, or Clinician Supported PTSD Coach App, is more effective. They are also looking at whether changing therapies after four sessions, based on how well you're responding, helps more than sticking with the same therapy. The goal is to find the best way to reduce PTSD symptoms using resources efficiently. To join, you must receive care at a participating health center, have a certain PTSD symptom score (PCL-5 score of 33 or higher), own a mobile device for the PTSD Coach App, and have stable psychotropic medication for at least 4 weeks. The main way they'll measure success is by looking at changes in your PTSD symptoms after 3 months.

Study design
This interventional study plans to enroll 430 participants. It is testing different talk therapy approaches for PTSD.
What's involved
Participants will receive one of three talk therapies: Prolonged Exposure for Primary Care (4 weekly 30-minute sessions), Full Prolonged Exposure (8 weekly 60-minute sessions), or Clinician Supported PTSD Coach App. You will also complete assessments at the start and after 3 months.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptoms will be measured at the start of the study and again after 3 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05457985

Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers

Recruiting
NAAges 18+InterventionalTreatment
University of Michigan
~430 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:Prolonged Exposure for Primary Care (PE-PC)Full Prolonged ExposureClinician Supported PTSD Coach App

At a glance

Recruiting sites
12 of 13 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in PTSD symptoms as measured by the Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 (CAPS-5)
Measured over Baseline, 3-months

Conditions

PTSD

Explore related trials

Post-Traumatic Stress Disorder

Where it's being run

13 sites across 5 states
Michigan9
Missouri1
North Carolina1
Texas1
Washington1

Who to contact

Kayla Longuski, MS
[email protected]
734-647-6258
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Receive care at a participating federally qualified health center (FQHC)
Have a Posttraumatic Stress Disorder checklist (PCL-5) score greater or equal (≥) to 33
Own a mobile device that can be used for the PTSD Coach App
Have had psychotropic medication stability for at least 4 weeks

Exclusion

Severe cognitive impairment that in the judgment of the investigators makes it unlikely that the participant can adhere to the study regimen (as evidenced by confusion, inability to track discussion or answer questions, or other clear and significant indicators of cognitive impairment)
High risk of suicide (defined as meeting criteria for Action Step 3 on the Participant Suicide Risk Screening form
Severe alcohol or substance use disorder (moderate-severe alcohol use disorder on Alcohol Use Disorders Identification Test (AUDIT) (scores ≥ 15) or high risk on National Institute on Drug Abuse Quick Screen (scores ≥ 27))
Active psychosis or unmanaged bipolar disorder
Unstable housing
Current engagement in a trauma-focused behavioral treatment (such as Prolonged Exposure or Cognitive Processing Therapy).
Patients who do not speak English will be excluded for logistical reasons.

What this trial measures

  • Change in PTSD symptoms as measured by the Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 (CAPS-5)Baseline, 3-months

    The CAPS-5 is a clinician-rated PTSD rating scale consisting of 30 items; the total score is calculated as the sum of 20 items assessing the 20 DSM-5 PTSD symptoms. These symptom items are scored on a 5-point scale from 0 (absent) to 4 (extreme/incapacitating). The total score of the 20 items ranges from 0 to 80 with higher scores indicating more severe PTSD symptoms. Therefore, a decrease in the total score indicates symptom improvement.