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Inspiratory Muscle Strength Training for Adults with Obesity

This study is looking at whether a special type of breathing exercise, called inspiratory muscle strength training, can help lower blood pressure in adults who have obesity. Participants will use a small handheld device daily for eight weeks to make breathing in a little harder. Some will use a high-resistance device, while others will use a very-low-resistance device. We are looking for adults aged 18 to 45 with a body mass index (BMI) between 30 and 40 kg/m2. You cannot join if your weight has changed a lot recently or if you have certain health conditions like uncontrolled high blood pressure. The main goal is to see if this training changes your blood pressure.

Study design
This is an interventional study planning to enroll 44 participants. It is designed as a randomized, double-blinded, sham-controlled trial.
What's involved
Participants will perform inspiratory muscle strength training daily for eight weeks using a handheld device. Blood pressure will be measured up to 16 weeks.
Compensation
Not stated in the trial record.
Follow-up
Blood pressure will be measured up to 16 weeks after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05459636

Inspiratory Muscle Strength Training in Adults With Obesity

Active, Not Recruiting
NAAges 18–45InterventionalBasic science
Florida State University
~44 participants
Updated 2026-08-27 on ClinicalTrials.gov
What's tested:High-resistance inspiratory muscle strength trainingVery-low-resistance inspiratory muscle strength training

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in laboratory-measured blood pressure
Measured over Up to 16 weeks

Conditions

Obesity

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
Florida1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Not weight stable (\<5% change in body mass over the past six months)
Overt cardiovascular, neurological, renal, liver, and/or metabolic illness (e.g., diabetes mellitus)
Current, or history of uncontrolled, Stage 2 hypertension (blood pressure \>140 / 90 mmHg; anti-hypertensive medications are permitted)
Diagnosed obstructive sleep apnea
Previous bariatric surgery
Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)
Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)
Pregnant (self-reported and confirmed via urine pregnancy test), lactating (self-reported), or post-menopausal (self-reported) females
Prisoners
Per the POWERbreathe® company:
Patients who have undergone recent abdominal surgery and those with abdominal hernia.
Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnea.
If a patient is suffering from a ruptured eardrum or any other condition of the ear.
Patients with marked elevated left ventricular end-diastolic volume and pressure.
Patients with worsening heart failure signs and symptoms after training.
If an individual is suffering from a cold, sinusitis or respiratory tract infection, it is advised that they do not use the POWERbreathe device.

What this trial measures

  • Change in laboratory-measured blood pressureUp to 16 weeks

    Systolic and diastolic blood pressure measured in the laboratory