Neuromodulation of Memory in Aging with Transcranial Magnetic Stimulation
This study is exploring a treatment called Transcranial Magnetic Stimulation (TMS) for people with Mild Cognitive Impairment (MCI) and healthy older adults. TMS uses magnetic fields to stimulate brain cells and may help improve memory. Researchers want to see if TMS, when tailored to your individual brain networks, can reliably control brain states related to memory. They will measure how TMS affects your working memory performance and brain activity. You may be able to join if you are between 18 and 75 years old, speak English, and are willing to give consent. The study aims to enroll 150 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 150 participants, including those with Mild Cognitive Impairment and healthy older adults.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study measures working memory during TMS-EEG (Day 4) and brain connectivity and vascular density during initial neuroimaging sessions (Day 2 and Day 3).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Neuromodulation of Memory in Aging
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Simon W Davis, PhD · PRINCIPAL_INVESTIGATOR · Duke University
- Andy Liu, MD · PRINCIPAL_INVESTIGATOR · Duke University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Working Memory TaskCollected during TMS-EEG (Day 4)
The difference in memory accuracy between TMS conditions (random vs. ordered vs. sham stimulation) on a working memory task. Each trial of the task consists of stimulus presentation of an array of letters, a delay period in which subjects alphabetize the letters, and probe period where subjects indicate whether the number corresponds to the alphabetized position of the letter probe presented. Memory is subsequently assessed as a function of TMS condition.
- Functional network connectivityCollected during the initial neuroimaging session (Day 2)
Functional network connectivity/activity is estimated by comparing the hemodynamic time courses of two or more regions of the brain. The correlation between the time courses of each pair of regions is termed functional network connectivity. The Working Memory Network (WMN) is identified by comparing fMRI-based functional network connectivity for high vs low working memory load (e.g., remembering 4 versus 3 items).
- Vascular density (VAD)Collected during the second neuroimaging session (Day 3)
This measure of neurovascular brain health, vascular density (VAD), as estimated by an automated method of segmenting veins with a magnetic resonance imaging (MRI) sequence known as susceptibility weighted imaging. This measure can be used to estimate the dilation of cerebral veins, and therefore VAD.
- EEG-based connectivityCollected during TMS-EEG (Day 4)
EEG data will be source reconstructed to a fine-grained grid and timecourses of the solution points are averaged per region and per subject. The imaginary part of the coherence (iCoh) of averaged EEG source signals will be assessed within the alpha and theta frequency bands to build EEG-based connectivity matrices ("connectomes") for alpha- and theta-based connectivity, for each subject.