NCT05462600
Distribution of Ventilation, Respiratory Drive and Gas Exchange: Measurements and Monitoring
Enrolling by Invitation
Not specifiedAges 18+ObservationalUniversity of California, San DiegoInvestigator-initiated
~40 participants
Updated 2025-04-11 on ClinicalTrials.gov
What's tested:Position change
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Distribution of ventilation
Measured over 3 hours
+3 more outcomes measured
Conditions
Where it's being run
1 sites across 1 statesCalifornia1
Study leadership
- Alex Pearce · PRINCIPAL_INVESTIGATOR · University of California, San Diego
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
18 years or older
Non-smokers
Exclusion
\<18 years old
Significant history of pulmonary disease
Chest wall, anatomical, physical abnormalities, skin integrity issues precluding placement of electrode belt in direct contact with skin
Skin integrity issues precluding placement of nose clips, or transcutaneous carbon dioxide monitoring
Inability to form a seal around a mouthpiece
Known esophageal strictures, webs, or varices (if esophageal manometry to be included)
Known platelet count \< 100,000 (if esophageal manometry to be included)
On therapeutic anticoagulation (if esophageal manometry to be included)
Known multidrug resistant (MDR) pulmonary infection
Non-English language speakers
Chronic hypoxemic respiratory failure
Confirmed or suspected intracranial bleed, stroke, edema
Active implants (i.e. implantable electronic devices such as pacemakers, cardioverter defibrillators or neurostimulators) or if device compatibility is in doubt
Pregnant or lactating patients as safety and efficacy for use of EIT in such cases has not been verified
What this trial measures
- Distribution of ventilation3 hours
Change in regional ventilation distribution (ventral/dorsal) measured through electrical impedance tomography (EIT)
- Respiratory drive3 hours
Respiratory drive differences will be measured by mean desaturation (change from baseline percent oxygen saturation) following breath-hold maneuvers
- Respiratory drive3 hours
Respiratory drive differences will be assessed by the duration of maximal breath-hold (seconds)
- Respiratory drive3 hours
Respiratory drive will also be assessed by measurement of occlusion pressure (cm H2O) at 100 ms (P0.1) after the initiation of an inspiratory effort against a closed circuit.