Preoperative Radiation Therapy for Stage I Breast Cancer
This study is testing a new way to give radiation therapy (RT) before surgery for women with early-stage breast cancer. The goal is to find the highest dose of RT that can be given safely. Researchers will start with a standard dose of 30 Gy in 5 treatments and then increase the dose in groups of participants to 35 Gy, 40 Gy, and 50 Gy. You may be able to join if you are a woman aged 50 or older with a breast cancer tumor that is 3 cm or less (invasive) or 4 cm or less (DCIS). The study is looking for 15 participants and is currently unclear if it is recruiting.
- Study design
- This is an interventional study that will enroll 15 participants. It is a dose escalation study, meaning different groups of participants will receive increasing doses of radiation.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The maximum tolerated dose will be measured for up to 18 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Preoperative Irradiation for Stage I Breast Cancer
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Parul Barry, MD · PRINCIPAL_INVESTIGATOR · UPMC Hillman Cancer Center
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
What this trial measures
- Maximum tolerated dose (MTD)Up to18 months (cohort)
Maximum tolerated dose (MTD) of RT, which will be defined based on the occurrence of grade 2 or higher acute radiation dermatitis as defined per National Cancer Institute, Common Terminology Criteria for Adverse Events (CTCAE) v5.0, occurring within approximately 1 month after radiation therapy (RT). Dose escalation will begin with 30 GY and be escalated to 35, 40, and 50 GY as tolerated.