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Studying Cannabis Use and Brain Health in Older Adults

This study is looking at how cannabis use might affect brain health in older adults. Researchers will use a special type of brain scan called a [11C]UCB-J PET (Positron Emission Tomography) to measure something called synaptic density in the hippocampus (a part of your brain important for memory). They want to see if cannabis use changes this density. You may be able to join if you are 50 years or older, have no major medical or brain conditions, and have a BMI (Body Mass Index) of 50 or less. The study aims to enroll 24 participants, but its current status is unclear.

Study design
This is an interventional study involving a single PET scan. It plans to include 24 participants.
What's involved
You would undergo a single [11C]UCB-J PET scan.
Compensation
Not stated in the trial record.
Follow-up
Your hippocampal synaptic density will be measured at 1 month after the scan.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05465538

SV2A in Older Adults

Recruiting
PHASE1Ages 50+Interventional
Yale University
~24 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:[11C]UCB-J PET

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hippocampal synaptic density
Measured over 1 month

Conditions

Cannabis Use

Explore related trials

Cannabis misuse

Where it's being run

1 sites across 1 states
Connecticut1

Study leadership

  • Deepak C D'Souza, MBBS, MD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Angerlyk Frytz, MD
[email protected]
203-974-7822
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Able to provide informed consent
Male or female, aged ≥50 years
No history of significant medical or neurological disease
BMI ≤ 50
If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans

Exclusion

Women with a positive pregnancy test or women who are lactating
Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
History of a bleeding disorder or are currently taking anticoagulants
Subjects who have donated blood within 8 weeks of the present study

What this trial measures

  • Hippocampal synaptic density1 month

    Measure of synaptic density in the hippocampus