Genetic Testing Decision Aid for Ovarian and Pancreatic Cancer

This study is testing two ways to help people with ovarian or pancreatic cancer understand genetic testing. You would either use an electronic decision aid (a computer program to help you make choices) or receive pre-test genetic counseling (talking with a genetic expert). The study wants to see which method helps you learn more, feel more confident in your decisions, and participate more in shared decision-making with your doctor. To join, you must be 18 or older, be seen at Massachusetts General Hospital or Boston Medical Center, and have been diagnosed with malignant epithelial ovarian carcinoma (a type of ovarian cancer) or malignant pancreatic adenocarcinoma (a type of pancreatic cancer). The study is currently recruiting about 350 people.

Study design
This is a randomized interventional study, meaning participants will be assigned by chance to one of two groups. About 350 people are expected to participate.
What's involved
You would complete surveys and questionnaires in conjunction with either a genetic counselor visit or using the electronic decision aid. The study procedures will last up to 2 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your knowledge, decisional conflict, and shared decision-making will be measured at 1 week after your genetics session, which is approximately 2 weeks after baseline.

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NCT05470920

Genetic Testing Decision Aid

Recruiting
NAAges 18+InterventionalHealth services
Massachusetts General Hospital
~350 participants
Updated 2025-08-13 on ClinicalTrials.gov
What's tested:Electronic Decision AidPre-Test Genetic Counseling

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Average change in knowledge survey score
Measured over baseline (prior to participant completing either genetics sessions) to 1-week following session, approximately 2 weeks
+2 more outcomes measured
Epithelial Ovarian Carcinoma
Pancreas Adenocarcinoma
2 sites across 1 states
Massachusetts2
  • Daniel C. Chung, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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Eligibility criteria

Inclusion

18 years or older
Being seen in clinic at Massachusetts General Hospital or Boston Medical Center
Diagnosed with malignant epithelial ovarian carcinoma or malignant pancreatic adenocarcinoma.

Exclusion

Unable or unwilling to provide informed consent, undergo randomization, or complete the surveys associated with the study
Previous germline genetic testing
History of hereditary pancreatitis
Members of the following vulnerable populations: adults unable to consent, individuals who are not yet adults
  • Average change in knowledge survey scorebaseline (prior to participant completing either genetics sessions) to 1-week following session, approximately 2 weeks

    Average change in score on a 10-question knowledge survey to assess basic information about genetics and genetic testing that was covered in their appointment. Scores on the scale range from 0-10. Higher values in the change in knowledge survey score suggest greater amount of knowledge gained in the genetics session.

  • Decisional Conflict Scores1 week after genetics session

    The decisional conflict score is a score ranging from 0-100 that is measured from a 10-question validated decisional conflict scale. The scale assesses participant's confidence in their decision with higher scores indicating higher decisional conflict.

  • Shared Decision Making Process Scores1 week after genetics session

    The shared decision making process score is a score on a scale of 1-4 based on responses on a validated 4-item shared-decision making scale. The scale assesses how well the decision aid/oncology provider, or the genetic counselor engaged in shared decision-making as perceived by the subject. Higher scores on this scale indicate more shared decision making.