This study is looking at how cannabis use disorder (CUD) affects the brain. Researchers want to see if the density of synaptic vesicles (tiny sacs that store brain chemicals) in a part of the brain called the hippocampus changes after at least four weeks of not using cannabis. They will use a special brain scan called a PET scan with a drug called [11C]APP311 (UCB-J) to measure this. They will compare people with CUD to healthy individuals. The study also aims to see if these brain changes are linked to memory and how much cannabis someone has used over time. You may be able to join if you are 18-75 years old, use cannabis daily, have a CUD diagnosis, and are willing to try to quit.

Study design

This is an interventional study planning to enroll 51 participants, including individuals with Cannabis Use Disorder and healthy controls.

What's involved

Participants will receive at least two [11C]APP311 (UCB-J) PET scans, given approximately four weeks apart.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint measures changes in hippocampal SV2A synaptic density approximately four weeks after the first scan.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.