Observational Study on CF Carrier State and Organ Health

This observational study is looking into whether being a carrier for cystic fibrosis (CF) might increase the risk of developing certain health issues, specifically affecting the pancreas and kidneys. Researchers believe that CF carriers might show early, subtle signs of these conditions compared to people who are not CF carriers. The study aims to compare glucose (blood sugar) and insulin levels between CF carriers and non-carriers. You could be eligible if you are between 18 and 100 years old and are a confirmed CF carrier or have never been tested for CF. You cannot participate if you have CF, are pregnant, or are taking diabetes medication. The study involves one clinic visit where you'll answer questions and have lab tests. Some participants will also collect urine and stool samples at home.

Study design
This is an observational study planning to enroll 1250 participants. It compares health markers in CF carriers to those who are not CF carriers.
What's involved
You will have one clinic visit for measurements, blood pressure, blood draws, and a 2-hour oral glucose tolerance test. Some participants will also collect urine and stool samples at home.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for glucose and insulin values are taken at baseline (at the start of the study).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05474417

The Effects of the CF Carrier State on the Kidneys and Pancreas

Recruiting
Not specifiedAges 18+Observational
Philip Polgreen
~1,250 participants
Updated 2026-01-07 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Comparison of Glucose Values
Measured over At baseline
+1 more outcome measured
Carrier State
Pancreatic Disease
Kidney Diseases
1 sites across 1 states
Iowa1
  • Philip M Polgreen, MD · PRINCIPAL_INVESTIGATOR · University of Iowa

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

A CF Carrier identified via genetic testing
No previous CF carrier test results

Exclusion

CF patient status
Unable to speak English
Currently pregnant
Unable to provide written informed consent
Prisoner status
Currently taking any medications for the treatment of diabetes
  • Comparison of Glucose ValuesAt baseline

    Comparison of glucose values in cystic fibrosis carrier group vs control group via t-tests.

  • Comparison of Insulin ValuesAt baseline

    Comparison of insulin values in cystic fibrosis carrier group vs control group via t-tests.