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Observational Study on CFTR Heterozygosity and Respiratory Infections

This study aims to understand if being a carrier for cystic fibrosis (CF) affects your risk of respiratory infections. Researchers will compare chloride and bicarbonate transport values, and airway surface liquid pH (a measure of acidity) in people who are CF carriers versus those who are not. You can join if you are between 18 and 100 years old and speak English. If you are a CF carrier, you must have been previously tested. If you are not a CF carrier, you must have been previously tested and shown not to be a CF patient. The study is currently unclear on its recruitment status and does not involve any specific interventions or drugs.

Study design
This is an observational study planning to enroll 160 participants. It compares two groups: CF carriers and non-carriers.
What's involved
You will have a nasal brush procedure to collect cells and two blood draws. You will also answer questions about your health and medications in an interview.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT05474430

Estimating Risk of Respiratory Infections Attributable to CFTR Heterozygosity

Recruiting
Not specifiedAges 18+Observational
Philip Polgreen
~160 participants
Updated 2026-01-07 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Comparison of Chloride Transport Values
Measured over At baseline
+4 more outcomes measured

Conditions

Carrier State
Respiratory Infections

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Carrier of disorderRespiratory tract infectionCFTR Gene

Where it's being run

1 sites across 1 states
Iowa1

Study leadership

  • Philip M Polgreen, MD · PRINCIPAL_INVESTIGATOR · University of Iowa

Who to contact

Philip M Polgreen, MD
[email protected]
(319) 384-6194
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Previously tested and shown to be a CF carrier
English-speaking
Previously tested and shown to not be a CF carrier or CF patient
English-speaking

Exclusion

Currently sick with a respiratory infection
Prisoner Status
Unable to provide own written, informed consent

What this trial measures

  • Comparison of Chloride Transport ValuesAt baseline

    Comparison of chloride transport values in cystic fibrosis carrier group vs control group via t-test.

  • Comparison of Bicarbonate Transport ValuesAt baseline

    Comparison of bicarbonate transport values in cystic fibrosis carrier group vs control group via t-test.

  • Comparison of Airway Surface Liquid pH ValuesAt baseline

    Comparison of airway surface liquid pH values in cystic fibrosis carrier group vs control group via t-test.

  • Comparison of Mucous Viscosity ValuesAt baseline

    Comparison of mucous viscosity values in cystic fibrosis carrier group vs control group via t-test.

  • Comparison of Bacterial Killing ValuesAt baseline

    Comparison of bacterial killing values in cystic fibrosis carrier group vs control group via t-test.