Targeted tDCS for Post-Stroke Upper Limb Motor Impairments

This study is looking at how a special type of brain stimulation, called high-definition transcranial direct current stimulation (tDCS), might help reduce arm and hand movement problems after a stroke. Researchers want to see if applying 20 minutes of 2 mA tDCS to specific brain areas can improve movement. You might be able to join if you are between 18 and 90 years old and have weakness on one side of your body, especially in your arm, due to a stroke. The study will measure changes in how your brain and muscles respond to stimulation to see if the tDCS is effective. The current status of this study is unclear, and it plans to enroll 30 participants.

Study design
This is a sham-controlled, double-blinded (meaning neither you nor the assessors will know which treatment you receive) crossover study involving 30 participants.
What's involved
You will have four visits, each lasting up to 3 hours, with at least a two-week break between visits. Your total time commitment will be about 10 weeks.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken at your initial visit, and then before and immediately after each intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05479006

Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments

Recruiting
NAAges 18–90InterventionalBasic science
Carle Foundation Hospital
~30 participants
Updated 2025-12-19 on ClinicalTrials.gov
What's tested:Transcranial direct current stimulation (high- definition)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Transcranial Magnetic Stimulation-Evoke Motor-evoked Potential 1: Ispilesional stimulation in the brain and contralateral response in the muscle
Measured over Baseline (initial visit), before (within 30 min range) and immediately after (within 30 min range) the intervention
+1 more outcome measured
Stroke

NCT05479006

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Carle Foundation Hospital

    Urbana, Illinoisstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Paresis confined to one side, with substantial motor impairment of the paretic upper limb
Capacity to provide informed consent

Exclusion

Muscle tone abnormalities and motor or sensory impairment in the non-paretic limb
Severe wasting or contracture or significant sensory deficits in the paretic upper limb
Severe cognitive or affective dysfunction that prevents normal communication and understanding of consent or instruction
Severe concurrent medical problems (e.g. cardiorespiratory impairment)
Using a pacemaker
Metal implants in the head
Known adverse reactions to TMS and tDCS
Pregnant
  • Change in Transcranial Magnetic Stimulation-Evoke Motor-evoked Potential 1: Ispilesional stimulation in the brain and contralateral response in the muscleBaseline (initial visit), before (within 30 min range) and immediately after (within 30 min range) the intervention

    This is a neurophysiological measure that determines the use of the ipsilesional corticospinal tract.

  • Change in Transcranial Magnetic Stimulation-Evoke Motor-evoked Potential 2: Contralesional stimulation in the brain and ipsilateral response in the muscleBaseline (initial visit), before (within 30 minutes range) and immediately after (within 30 minutes range) the intervention

    This is a neurophysiological measure that determines the use of the contralesional cortico-reticulospinal tract.