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Evaluation of Endometriosis With 18F-fluorofuranylnorprogesterone PET / MRI

{ "Evaluating Endometriosis with 18F-fluorofuranylnorprogesterone PET/MRI", "This study is looking at a new way to diagnose endometriosis using a special scan called 18F-fluorofuranylnorprogesterone PET/MRI. This scan uses a tracer called 18F-fluorofuranylnorprogesterone to help doctors see endometriosis more clearly. The goal is to see how well this scan can find (sensitivity) and correctly identify (specificity) endometriosis. We are looking for 24 women, aged 18 to 55, who are suspected of having endometriosis and are planning to have surgery. Your participation would help us understand if this new imaging method could be a useful tool for diagnosing endometriosis in the future.", "design": "This is a single-center study involving 24 participants. It is a prospective, one-arm study, meaning all participants will receive the same intervention.", "commitments": "You would receive a PET/MRI scan with the 18F-fluorofuranylnorprogesterone tracer. You must also be scheduled for a planned operative laparoscopy and not be on hormone treatment for at least two cycles.", "compensation": "Not stated in the trial record.", "follow_up": "The main results will be measured upon completion of all study image data collection for all participants, which is expected to be approximately 1 year.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05480995

Evaluation of Endometriosis With 18F-fluorofuranylnorprogesterone PET / MRI

Active, Not Recruiting
PHASE2Ages 18–55InterventionalDiagnostic
University of North Carolina, Chapel Hill
~9 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:18F-fluorofuranylnorprogesterone PET / MRI

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sensitivity of 18F-fluorofuranylnorprogesterone (FFNP) PET/MR for evaluating endometriosis
Measured over Upon completion of all study image data collection for all participants [approximately 1 year]
+1 more outcome measured

Conditions

Endometriosis

Explore related trials

Endometriosis

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Jorge Oldan, MD · PRINCIPAL_INVESTIGATOR · University of North Carolina, Chapel Hill

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18 or older
Female of childbearing age (18-55 years)
Clinically suspected (symptomatic) endometriosis as defined by referring physician (this would also include endometriomas as other disease may be present).
Scheduled for planned operative laparoscopy with no hormone treatment for at least two cycles
Able to provide informed consent

Exclusion

Male
Institutionalized subject (prisoner or nursing home patient)
Known history of breast, ovarian or endometrial cancer.
Pregnant or breast-feeding women
Chronic progestin-containing medications or Gonadotropin-releasing hormone (GnRH) analogues in the last 10-16 days (or 2 cycles in the case of GnRH analogues as these are dosed monthly) or inability to discontinue these medications
Allergy to gadolinium contrast or Glomerular Filtration Rate (GFR) below 30 ml/min.

What this trial measures

  • Sensitivity of 18F-fluorofuranylnorprogesterone (FFNP) PET/MR for evaluating endometriosisUpon completion of all study image data collection for all participants [approximately 1 year]

    The sensitivity of FFNP PET /MR is defined as the ability of readers (radiologists) to correctly detect endometriosis in patients who have endometriosis.

  • Specificity of 18F-fluorofuranylnorprogesterone (FFNP) PET/MR for evaluating endometriosisUpon completion of all study image data collection for all participants [approximately 1 year]

    The specificity is similarly defined as the ability of readers to exclude endometriosis in patients who do not have it.