Sensory Filtering in Parkinson's Disease
This study is looking at how the brain processes sensory information in people with Parkinson's disease. Researchers want to understand if a part of the brain called the basal ganglia helps "filter out" unimportant sensory signals and how this relates to movement problems. You may be able to join if you are an adult (18-89 years old) with advanced Parkinson's disease who is planning to have Deep Brain Stimulation (DBS) surgery. During the study, you would perform tasks involving sensory stimuli (like sights or touches) while brain activity is recorded during and after your DBS surgery. The study aims to see how your body responds to these stimuli, both during the surgery and one month later. This is an observational study, meaning researchers are watching and recording, not testing a new treatment. The study plans to enroll 30 participants, but its current recruitment status is unclear.
- Study design
- This is an observational study that plans to enroll 30 participants. It is not testing a new treatment but rather observing brain activity.
- What's involved
- You would perform behavioral tasks involving sensory stimuli during your DBS surgery and again one month after surgery. This involves responding to stimuli while brain activity is recorded.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your body's response to stimuli will be measured one month after your DBS surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease
At a glance
Conditions
NCT05482126
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
The University of Alabama at Birmingham Hospital
Birmingham, Alabamastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Zachary Irwin, PhD · PRINCIPAL_INVESTIGATOR · The University of Alabama at Birmingham
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Kinematic response to stimulus (intraoperative)Intraoperative
Arm movements (hand position, velocity) recorded following stimulus onset, measured by joystick outputs.
- Kinematic response to stimulus (postoperative)1 month post-op
Arm movements (hand position, velocity) recorded following stimulus onset, measured by joystick outputs.
- Latency of response to stimulus (intraoperative)Intraoperative
Time from stimulus onset to start of motor response, measured by electromyography (EMG)
- Latency of response to stimulus (postoperative)1 month post-op
Time from stimulus onset to start of motor response, measured by electromyography (EMG)
- Neural response to stimulusIntraoperative
Brain activity recorded following stimulus onset, measured by local field potentials recorded from the electrocorticography (ECoG) and DBS electrodes.