This study is looking at the best way to treat severe sepsis and septic shock, which are serious conditions caused by the body's overwhelming response to an infection. Researchers are comparing two different approaches to delivering a "sepsis bundle" – a set of treatments that includes measuring lactate levels, taking blood cultures, and giving broad-spectrum antibiotics. One approach delivers these treatments within 1 hour, and the other within 3 hours. The goal is to see which method leads to better survival rates for patients. This study will enroll up to 10,000 adults aged 18 and older who meet specific criteria for sepsis upon arrival at the emergency department. The main way to measure success is by looking at mortality (death) rates 28 days after treatment.

Study design

This is an interventional study comparing two different treatment approaches for sepsis, with a planned enrollment of 10,000 participants.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Participants' mortality will be measured at 28 days after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.