Deep Brain Stimulation Optimization for Refractory Epilepsy
This study is looking for 20 adults (18 years or older) who have epilepsy that doesn't respond well to medication (medically refractory epilepsy) and already have a deep brain stimulator (DBS) implanted. The goal is to find the best settings for your DBS device to reduce seizures. Researchers will test different orders of stimulation settings (PS and OS stimulation orders 1, 2, and 3) and measure how these changes affect brain activity over one year. This will help them learn how to fine-tune DBS for each patient.
- Study design
- This study plans to enroll 20 participants. It is an interventional study, meaning participants will receive specific interventions.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for one year from baseline to measure changes in brain activity.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Robert McGovern, MD · PRINCIPAL_INVESTIGATOR · University of Minnesota
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Difference in broadband power with different settingsOne year from baseline
Different settings include different combinations of stimulation amplitude, frequency and pulse width. The full spectrum PSD data from all of the in-clinic recordings at all of the unique settings will be combined to look at the resulting difference in broadband power.
- Difference in frequency band-specific low-frequency power (LFP) with different settingsOne year from baseline
Different settings include different combinations of stimulation amplitude, frequency and pulse width. The full spectrum PSD data from all of the in-clinic recordings at all of the unique settings will be combined to look at the resulting difference in frequency band-specific LFP.