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NCT05494398

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Open Label

Enrolling by Invitation
PHASE2Ages 3–13InterventionalTreatment
Stanford University
~144 participants
Updated 2026-05-15 on ClinicalTrials.gov
What's tested:N-acetylcysteine

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in glutamatergic neurometabolites (Glx) measured by proton spectroscopy Magnetic Resonance Imaging (MRI)
Measured over Baseline and Week 12 of treatment
+1 more outcome measured

Conditions

Autism Spectrum Disorder

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Autism Spectrum Disorder

NCT05494398

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Stanford University School of Medicine

    Stanford, Californiano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • John Hegarty, PhD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

participation in an associated single-dose (IRB-54931, NCT04278898) or randomized, controlled trial of NAC (IRB- 68353, NCT05664789).
stable medication regimens (≥ 30 days) with no anticipated changes during the trial.

What this trial measures

  • Change in glutamatergic neurometabolites (Glx) measured by proton spectroscopy Magnetic Resonance Imaging (MRI)Baseline and Week 12 of treatment
  • Change in restricted and repetitive behaviors as measured by Children's Yale Brown Obsessive Compulsive Scale - Autism Spectrum Disorder (CYBOCS-ASD)Screening, Week 8, week 12

    Higher scores on the Children's Yale Brown Obsessive Compulsive Scale - Autism Spectrum Disorder mean higher levels of restricted and repetitive behaviors (Raw Score Total Range: 0-20)