Understanding Stress and Resilience with the Maya App

This study is looking for healthy incoming freshmen students at the University of Michigan, aged 18-22, to understand how people respond to stress. It aims to find biological indicators (biomarkers) that show who is more vulnerable to stress and who is more resilient (able to recover easily). You would use the Maya App, a mobile program that teaches techniques like emotion monitoring and mindfulness for anxiety, for at least 20 minutes a day, two days a week, for six weeks. Researchers will measure changes in anxiety and depressive symptoms using surveys like the GAD-7, PHQ-9, and STAI over 12 months. The study's current status is unclear.

Study design
This is an interventional study with a planned enrollment of 500 participants. It compares those who use the Maya App to those who do not.
What's involved
You would use the Maya App for at least 20 minutes per day, 2 days per week, for 6 weeks. You would also complete assessments, including specimen collections, interviews, and surveys, at baseline, 3, 6, 9, and 12 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 12 months after the start of the study.

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NCT05498207

Identification of Biomarkers for Stress Vulnerability and Resilience

Recruiting
NAAges 18–22InterventionalTreatment
University of Michigan
~500 participants
Updated 2026-06-23 on ClinicalTrials.gov
What's tested:Maya App

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in anxiety symptoms based on the General Anxiety Disorder-7 Scale (GAD-7) between the intervention arm and the no intervention arm
Measured over Baseline, up to 12 months
+2 more outcomes measured
Healthy
1 sites across 1 states
Michigan1
  • Huda Akil, PhD · PRINCIPAL_INVESTIGATOR · University of Michigan

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Eligibility criteria

Inclusion

Incoming Freshmen Students at the University of Michigan

Exclusion

Suicidal Ideation
  • Change in anxiety symptoms based on the General Anxiety Disorder-7 Scale (GAD-7) between the intervention arm and the no intervention armBaseline, up to 12 months

    The GAD-7 is a 7 item questionnaire to measure the severity of anxiety symptoms (scores between 0-21). The items measure both psychic anxiety and somatic anxiety, where higher scores, defined by a score range of greater than or equal to 10, indicate a greater presence of symptoms and lower scores, defined by a score range of 0-9, indicate mild to no anxiety symptoms. Change in anxiety ratings between the intervention arm and the no intervention arm.

  • Change in depressive symptoms based on the Patient Health Questionnaire-9 (PHQ-9) between the intervention arm and the no intervention armBaseline, up to 12 months

    The PHQ-9 is a 9-item scale containing three subscales measuring physical, cognitive, and social concerns regarding depression. Higher scores, defined by a score range of greater than or equal to 10, reflect greater presence of symptoms and lower scores, defined by a score range of 0-9, indicate mild to no depression symptoms. Change in depression ratings between the intervention arm and the no intervention arm.

  • Change in anxiety symptoms based on the Spielberger State and Trait Anxiety Inventory (STAI) between the intervention arm and the no intervention armBaseline, up to 12 months

    The Spielberger State and Trait Anxiety Inventory is a validated self-reporting instrument used to assess anxiety. The inventory consists of state anxiety, which evaluates how the subject feels currently (transient anxiety) and trait anxiety (anxiety related to personality). The scale consists of 20 questions to determine state and 20 questions for trait anxiety with a 4-point Likert scale, a higher score indicates greater anxiety. Total score for state and trait measures ranges from 20 (no anxiety) to 80 (maximum anxiety). Change in anxiety ratings between the intervention arm and the no intervention arm.