Caloric Restriction and Glucagon in Type 2 Diabetes

This study is looking at how a special diet, called caloric restriction, affects how the body uses sugar and fats in people with Type 2 Diabetes. Researchers want to see if eating 900 calories a day, using meals from "Nutritional Guidelines after Bariatric Surgery," can improve how the body responds to glucagon (a hormone that raises blood sugar). You might be able to join if you are 25-65 years old, have Type 2 Diabetes managed by diet or oral medications, and a BMI of 28 or higher. The main goal is to measure how a specific amino acid (leucine) is used when glucagon levels change. The study is currently unclear on its status and plans to enroll 20 participants.

Study design
This is an interventional study with 20 planned participants. The phase of the study is not specified.
What's involved
You would follow a 900-calorie daily diet, with weekly meetings with a dietician. You would also undergo a hyperglycemic clamp procedure to measure glucagon's effects.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 240 minutes of study, which gives an indication of the measurement period.

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NCT05499702

The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction

Recruiting
PHASE2Ages 25–65InterventionalBasic science
Adrian Vella
~20 participants
Updated 2026-05-28 on ClinicalTrials.gov
What's tested:Caloric RestrictionHyperglycemic clamp

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of leucine oxidation in response to rising glucagon concentrations
Measured over 240 minutes of study
Type2diabetes
1 sites across 1 states
Minnesota1
  • Adrian Vella · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

We will recruit up to 20 weight-stable, subjects with type 2 diabetes
BMI ≥ 28 Kg/M2
Diabetes is managed by diet alone or a combination of oral agents

Exclusion

History of prior upper abdominal surgery e.g. gastric banding, pyloroplasty, vagotomy.
Active systemic illness or malignancy.
Symptomatic macrovascular or microvascular disease.
Contraindications to MRI (e.g. metal implants, claustrophobia).
Hematocrit \< 35%
TSH \< 0.4 or \> 5.5.
Consumption of \> 2 alcohol drinks per day or \> 14 per week or a positive AUDIT questionnaire.
  • Rate of leucine oxidation in response to rising glucagon concentrations240 minutes of study

    tracer-determined amino acid catabolism