Back to search results

Nicotinamide Riboside for Cognition and Sleep

This study is looking at whether a dietary supplement called nicotinamide riboside (NR), a form of vitamin B3, can improve sleep and thinking abilities in older adults. NR helps increase levels of NAD+ in the body, and low NAD+ has been linked to memory problems and sleep issues. You might be able to join if you are between 65 and 85 years old and have a Pittsburgh Sleep Quality Index (PSQI) score above 5, indicating poor sleep quality. However, you cannot participate if you have dementia (a VA-SLUMS score below 20). The main goal is to see how NR affects your sleep quality over 12 weeks. The study is currently recruiting 50 participants, but its status is unclear.

Study design
This interventional study plans to enroll 50 participants. It compares nicotinamide riboside to a placebo (an inactive pill).
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Sleep quality will be assessed at 12 weeks from the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05500170

Benefits of Nicotinamide Riboside Upon Cognition and Sleep

Recruiting
NAAges 65–85InterventionalSupportive care
State University of New York at Buffalo
~50 participants
Updated 2025-08-22 on ClinicalTrials.gov
What's tested:Nicotinamide ribosidePlacebo

At a glance

Recruiting sites
1 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sleep Quality Assessment
Measured over Change from baseline to endpoint at 12 weeks

Conditions

Cognitive Impairment
Sleep Quality

Explore related trials

Cognitive DysfunctionQuality of sleep

NCT05500170

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University at Buffalo State University of New York

    Buffalo, New Yorkstudy coordinator listed

    Not yet recruiting

  • Buffalo Veteran Affairs Medical Center

    Buffalo, New Yorkno site contact published

    Recruiting

  • State University of New York at Buffalo

    Buffalo, New Yorkno site contact published

    Not yet recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Carleara Weiss, PhD, MS, RN
[email protected]
7168282006
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5

Exclusion

Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20

What this trial measures

  • Sleep Quality AssessmentChange from baseline to endpoint at 12 weeks

    Sleep quality will be assessed with the Pittsburgh Sleep Quality Index , where global score \>5 indicates poor sleep quality and global score \<5 indicates good sleep quality.