Cryoablation vs. Steroid and Lidocaine for Morton's Neuroma

This study is comparing two ways to treat Morton's neuroma, a painful thickening of a nerve in your foot. Researchers are looking at cryoablation (freezing the nerve) versus a nerve block with steroid and lidocaine. You might be able to join if you are over 18, have Morton's neuroma confirmed by X-ray and ultrasound, and conservative treatments like orthotics haven't worked for at least four weeks. The study aims to see which treatment better improves your quality of life, reduces pain, and improves your foot function one year after the procedure. The current status of this study is unclear, and it plans to enroll 32 participants.

Study design
This interventional study plans to enroll 32 participants. It is comparing two different treatments for Morton's neuroma.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year after their procedure to assess changes in quality of life, pain, and function.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05501262

Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma

Recruiting
NAAges 18+InterventionalTreatment
Oregon Health and Science University
~32 participants
Updated 2025-10-16 on ClinicalTrials.gov
What's tested:CryoablationNerve block

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in quality of life
Measured over 1 year post procedure
+4 more outcomes measured
Morton Neuroma

NCT05501262

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Oregon Health Sciences University

    Portland, Oregonno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Claire Kaufman · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

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Eligibility criteria

Inclusion

Age \>18 years
Able to consent and complete questionnaires
Failure of a four-week trial of conservative therapy (includes orthotics, appropriate footwear, and/or metatarsal pads)
X-ray and ultrasound excluding other pathology and confirming the presence and location of a Morton's neuroma

Exclusion

Inability to follow-up or to comply with the follow-up protocol
Contraindication to cryoablation and/or lidocaine/steroid injection
Other pathology which could account for symptoms identified on imaging studies
Unwillingness to be randomized
  • Changes in quality of life1 year post procedure

    Will be evaluated using the SF-36 Quality of Life Survey

  • Réponse in pain1 year post procedure

    Will be evaluated using the visual analog scale with 0 as no pain and 10 as the word pain imaginable

  • Changes to function1 year post procedure

    Changes to the modified American Orthopedic Foot and Ankle Society Hallux Metatarsophalangeal--Interphalangeal Scale, higher score is less symptomatic

  • Changes pain and function due to neuroma1 year post procedure

    Changes in Neuroma Scale, higher score is less symptomatic

  • Incidence of Treatment - Emergent Adverse Events1 year post procedure

    Monitoring for safety of the treatment arm