FAST-therapy for Freezing of Gait in Parkinson's Disease
This study is testing a treatment called Function-based Accelerated Stimulation Therapy (FAST-therapy) for people with Parkinson's disease (PD) who experience "freezing of gait" (FOG). FOG is when you suddenly feel like your feet are stuck to the ground, making it hard to walk. FAST-therapy uses repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation device (MagPro X100), to target specific areas of the brain. The goal is to see if this treatment can improve walking difficulties that are not helped by standard Parkinson's medications. Researchers will measure how acceptable the treatment is to participants, how many people complete the study, and changes in walking ability using a test called the TUG (Timed Up and Go) test. You may be able to join if you are between 45 and 90 years old, have early-stage Parkinson's disease (H&Y2-3), and speak English. The study aims to enroll 20 participants.
- Study design
- This is an interventional study with a planned enrollment of 20 participants. The phase of the study is not specified.
- What's involved
- You would receive rTMS treatment over several days. Your perception of the treatment will be measured, and your walking ability will be tested before treatment, 48 hours after, and 14 days after the intervention.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed up within 1 week post-treatment, 48 hours post-intervention, and 14 days post-intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD)
At a glance
Conditions
NCT05509842
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Michigan
Ann Arbor, Michiganstudy coordinator listed
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Participant perception of treatment acceptabilityup to six treatment days
A study-specific questionnaire of rTMS treatment acceptability. Participants rate any perceived symptoms on a scale from 1 to 4 (none, mild, moderate, severe), with lower scores indicating better acceptability.
- Retention rateChange from Baseline prior to treatment and at follow-up within 1 week post-treatment
Percentage of participants enrolled who completed the study.
- Percentage change in TUG test time to 48 hours and 14 days post-interventionChange from Baseline; 48 hours post; 14 days post -intervention
Time to complete the full TUG protocol.
- Net changes in FOG-Q scores at 48 hours and 14 days post-interventionChange from Baseline; 48 hours post; 14 days post -intervention
Net changes in FOG-Q scores at 48 hours and 14 days post-intervention