Study on Probiotic Impact on PPI-Induced Gut Changes
This study is looking at how the probiotic Lactobacillus rhamnosus GG (found in Culturelle Digestive Probiotic) affects the microbes in your gut when you're taking omeprazole, a medicine like Prilosec that reduces stomach acid. We want to see if Lactobacillus rhamnosus GG can help with changes to your gut microbes that might happen when you take omeprazole. You can join if you are a healthy adult, aged 18 or older, without any current or chronic stomach or bowel symptoms, and you don't follow any special diets. The study will consider itself successful if it finds a change in the variety of gut microbes. The current status of this study is unclear, but it plans to enroll 30 participants.
- Study design
- This is an interventional study involving 30 healthy participants. It compares omeprazole with either Lactobacillus rhamnosus GG or a placebo (an inactive pill that looks like the study drug).
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your gut microbe diversity will be measured at the beginning of the study and again on Day 56.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- John DiBaise, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in Observed Operational Taxonomic Unit (OTU) diversity.Baseline, Day 56
Observed OTU counts in each stool sample will be tested at varying cutoffs by determining the number of OTUs per sample.