Light Therapy and Occupational Therapy for Genitourinary Cancer Fatigue

This study is looking into how light therapy and occupational therapy (a type of therapy that helps you do everyday activities) can help reduce fatigue (extreme tiredness) in people with genitourinary cancers (cancers of the urinary and reproductive organs, like prostate, kidney, or bladder cancer). Researchers want to see if these interventions, alone or together, can improve your energy levels. You might be able to join if you are 18 or older, speak English, are currently receiving cancer treatment (like chemotherapy or immunotherapy), and have mild to moderate fatigue. The study will measure changes in your fatigue levels over 3 months using questionnaires.

Study design
This study plans to enroll 224 participants and will randomly assign them to one of four groups to receive light therapy, occupational therapy, both, or usual care.
What's involved
You would either self-administer light therapy for 30 minutes daily for 3 months, attend 6 occupational therapy sessions, or do both. You will also complete questionnaires at the start, 6 weeks, and 3 months.
Compensation
Not stated in the trial record.
Follow-up
Your fatigue levels will be measured at 6 weeks and 3 months after starting the study interventions.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05519878

Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary Cancers

Recruiting
NAAges 18+InterventionalSupportive care
City of Hope Medical Center
~224 participants
Updated 2025-12-24 on ClinicalTrials.gov
What's tested:Best PracticeBright White Light TherapyOccupational TherapyQuestionnaire Administration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Functional Assessment of Cancer Therapy - (FACIT)
Measured over At baseline
+2 more outcomes measured
Bladder Carcinoma
Genitourinary System Neoplasm
Kidney Carcinoma
Prostate Carcinoma
1 sites across 1 states
California1
  • William Dale · PRINCIPAL_INVESTIGATOR · City of Hope Medical Center

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Eligibility criteria

Inclusion

Aged 18 and over
Sufficiently fluent in English
On active treatment receiving systemic therapy (e.g., chemotherapy, immunotherapy, hormonal therapy, etc.) or radiotherapy
Patients with diagnosis of a genitourinary (GU) cancer (e.g., prostate, kidney, and bladder cancer) who have grade 1 or 2 fatigue based on physician assessment at the time of study entry
Clinician assessed prognosis of greater than or equal to six months
Willing and independently able to provide consent
Receive a pre-screen FACIT-Fatigue score of less than or equal to 30

Exclusion

Severe sleep disorders (e.g. narcolepsy)
Eye Diseases which limit the ability of light to be processed (e.g. untreated cataracts, severe glaucoma, macular degeneration, blindness, pupil dilation problems or other retinal disorder)
Severe psychological impairment (e.g., bipolar disorder or manic episodes)
Current employment in night shift work
Previous use of light therapy to alleviate fatigue or depressive symptoms
Secondary cancer diagnosis within the past 5 years
Plans to travel across meridians during treatment
Pregnancy
Currently recovering from previous eye surgery within the past 6 months that causes eye irritation
Sensitivity to light, epilepsy, or a history of seizures
  • Functional Assessment of Cancer Therapy - (FACIT)At baseline

    The effects of light therapy and occupational therapy (OT) on FACIT will be evaluated by comparing light therapy to no-light therapy and comparing occupational therapy to no-occupational therapy. Analysis of variance test will be used for the factorial comparisons, with a two-sided statistical significance level (alpha = 0.05). The interaction between occupational therapy and light therapy will be explored (to understand whether the effect of light therapy \[if any\] on FACIT would change with occupational therapy and vice versa). The Functional Assessment of Chronic Illness Therapy (FACIT- fatigue scale) is a 13-item patient-reported measure of fatigue. Items are scored on a 0 - 4 response scale with anchors ranging from "Not at all" to "Very much so". To score the FACIT-fatigue, all items are summed to create a single fatigue score with a range from 0 to 52. The higher the score, the better the Quality of Life (QoL).

  • Functional Assessment of Cancer Therapy - (FACIT)6 weeks after baseline

    The effects of light therapy and occupational therapy (OT) on FACIT will be evaluated by comparing light therapy to no-light therapy and comparing occupational therapy to no-occupational therapy. Analysis of variance test will be used for the factorial comparisons, with a two-sided statistical significance level (alpha = 0.05). The interaction between occupational therapy and light therapy will be explored (to understand whether the effect of light therapy \[if any\] on FACIT would change with occupational therapy and vice versa). The Functional Assessment of Chronic Illness Therapy (FACIT- fatigue scale) is a 13-item patient-reported measure of fatigue. Items are scored on a 0 - 4 response scale with anchors ranging from "Not at all" to "Very much so". To score the FACIT-fatigue, all items are summed to create a single fatigue score with a range from 0 to 52. The higher the score, the better the Quality of Life (QoL).

  • Functional Assessment of Cancer Therapy - (FACIT)3 months after baseline

    The effects of light therapy and occupational therapy (OT) on FACIT will be evaluated by comparing light therapy to no-light therapy and comparing occupational therapy to no-occupational therapy. Analysis of variance test will be used for the factorial comparisons, with a two-sided statistical significance level (alpha = 0.05). The interaction between occupational therapy and light therapy will be explored (to understand whether the effect of light therapy \[if any\] on FACIT would change with occupational therapy and vice versa). The Functional Assessment of Chronic Illness Therapy (FACIT- fatigue scale) is a 13-item patient-reported measure of fatigue. Items are scored on a 0 - 4 response scale with anchors ranging from "Not at all" to "Very much so". To score the FACIT-fatigue, all items are summed to create a single fatigue score with a range from 0 to 52. The higher the score, the better the Quality of Life (QoL).