Back to search results
NCT05521958

Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

Enrolling by Invitation
NAAges 18–90Interventional
University of Utah
~80 participants
Updated 2026-04-29 on ClinicalTrials.gov
What's tested:Acute injury without compartment syndromeAcute injury with compartment syndromeExertional compartment syndrome

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Myostatin (% increase)
Measured over Immediately after the muscle tissue harvest procedure.

Conditions

Tibial Shaft Fracture
Tibial Plateau Fracture

Explore related trials

Compartment SyndromeFracture of tibial plateauNontraumatic exertional compartment syndromeTibia Fracture

Where it's being run

1 sites across 1 states
Utah1

Study leadership

  • Justin Haller, M.D. · PRINCIPAL_INVESTIGATOR · University of Utah Orthopaedics

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Patient 18+ years of age. English speaking.
Patients with the clinical diagnosis of lower leg acute compartment syndrome secondary to tibial shaft or tibial plateau fracture.
Patients without clinical compartment syndrome undergoing operative intervention within 48 hours of injury for tibial shaft or tibial plateau fractures.
Patients with the clinical diagnosis of exertional compartment syndrome with planned surgical intervention.

Exclusion

Non-english speaking participants

What this trial measures

  • Myostatin (% increase)Immediately after the muscle tissue harvest procedure.

    The investigators primary marker of interest is myostatin. The investigators will determine the (%) increase in myostatin levels in muscle tissues between compartment syndrome patients versus fracture controls. (%) increase in myostatin levels in muscle tissues between compartment syndrome patients versus patients with exertional compartment syndrome will also be determined. The measurement tool is polymerase chain reaction (PCR).