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NCT05521958

Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

Enrolling by Invitation
NAAges 18–90Interventional
University of Utah
~80 participants
Updated 2026-04-29 on ClinicalTrials.gov
What's tested:Acute injury without compartment syndromeAcute injury with compartment syndromeExertional compartment syndrome

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Myostatin (% increase)
Measured over Immediately after the muscle tissue harvest procedure.

Conditions

Tibial Shaft Fracture
Tibial Plateau Fracture

Explore related trials

Compartment SyndromeFracture of tibial plateauNontraumatic exertional compartment syndromeTibia Fracture

NCT05521958

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Utah Orthopaedic Center

    Salt Lake City, Utahno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Justin Haller, M.D. · PRINCIPAL_INVESTIGATOR · University of Utah Orthopaedics

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Patient 18+ years of age. English speaking.
Patients with the clinical diagnosis of lower leg acute compartment syndrome secondary to tibial shaft or tibial plateau fracture.
Patients without clinical compartment syndrome undergoing operative intervention within 48 hours of injury for tibial shaft or tibial plateau fractures.
Patients with the clinical diagnosis of exertional compartment syndrome with planned surgical intervention.

Exclusion

Non-english speaking participants

What this trial measures

  • Myostatin (% increase)Immediately after the muscle tissue harvest procedure.

    The investigators primary marker of interest is myostatin. The investigators will determine the (%) increase in myostatin levels in muscle tissues between compartment syndrome patients versus fracture controls. (%) increase in myostatin levels in muscle tissues between compartment syndrome patients versus patients with exertional compartment syndrome will also be determined. The measurement tool is polymerase chain reaction (PCR).