Studying Food Intake Regulation Using Functional MRI

This study is looking for healthy volunteers aged 21 to 50 with a BMI between 18-25 kg/m² to understand how your gut and brain respond to different types of food and how this affects your appetite. You'll undergo Functional Magnetic Resonance Imaging (fMRI) scans at different times. Researchers will also use an Intragastric Balloon (a balloon placed in your stomach and inflated), and you'll eat two types of meals: an Elemental Meal (a tasteless meal) and a Hedonic Meal (a meal of your choice). The main goal is to see how blood flow in a part of your brain called the hypothalamus changes after these interventions, measured after one month. The study is currently recruiting 15 participants, but its status is unclear.

Study design
This interventional study plans to enroll 15 healthy participants. It investigates how the brain and gut respond to different food stimuli.
What's involved
You will have multiple visits where you'll undergo MRI scans, have an Intragastric Balloon placed, and eat specific meals until you feel full.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, measuring brain blood flow, is assessed at one month.

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NCT05525845

Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI

Recruiting
NAAges 21–50InterventionalSupportive care
Mayo Clinic
~15 participants
Updated 2025-09-18 on ClinicalTrials.gov
What's tested:Functional Magnetic Resonance Imaging (pCASL-MRI)Intragastric BalloonElemental MealHedonic Meal

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in Cerebral Blood Flow related to hypothalamus
Measured over 1 month
Healthy
1 sites across 1 states
Minnesota1
  • Andres Acosta, MD, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

BMI 18-25 kg/m\^2.
Weight stable for 3 months prior to study entry.
For females: study days will be scheduled during the follicular phase of their menstrual cycle (i.e., the first 13 days (about 2 weeks) of the cycle).
Able to provide written informed consent prior to any study procedures and be willing and able to follow study procedures..
Ability to perform light to moderate physical activity.

Exclusion

Any contraindication for MRI scanning.
Any history of childhood (\> 95th percentile) or adult obesity (BMI \>30 kg/m\^2).
Claustrophobia.
High intensity training or physical activity.
Any contraindication for intragastric balloon insertion.
Any allergies to the study meals.
Any history of eating disorder.
Any substance abuse disorder (including alcohol and tobacco).
Any history of psychiatric disorders.
Any cardiovascular, endocrine, pulmonary, neurological, or gastrointestinal comorbidities.
Pregnancy or nursing.
Any history of bariatric surgery or endoscopic bariatric procedure.
Use of any medication or supplement that alters appetite.
Patient has a known history of any condition or factor judged by the investigator to prevent participation in the study or which might hinder study adherence.
  • Difference in Cerebral Blood Flow related to hypothalamus1 month

    The mean difference in cerebral blood flow (CBF) at fullness (satiation) and return to hunger (satiety) to the hypothalamic area.