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NCT05529264

Human Intracranial Electrophysiology

Recruiting
NAAges 18+InterventionalBasic science
Dartmouth-Hitchcock Medical Center
~175 participants
Updated 2026-01-15 on ClinicalTrials.gov
What's tested:Memory TasksAttention/arousal tasksLanguage tasksVisuospatial tasksAuditory TasksBrain Stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with memory.
Measured over Evaluated for each patient during monitoring period of approximately 2 weeks.
+5 more outcomes measured

Conditions

Epilepsy

Explore related trials

Seizure Disorder

Where it's being run

1 sites across 1 states
New Hampshire1

Study leadership

  • Krzysztof A Bujarski, MD · PRINCIPAL_INVESTIGATOR · Dartmouth-Hitchcock Medical Center

Who to contact

Krzysztof A Bujarski, MD
[email protected]
603-650-5104
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Eligibility criteria

Inclusion

Patients must be age 18 years or older. There is no upper age limit.
Patients must have a diagnosis of refractory epilepsy undergoing intracranial EEG recording for clinical purposes.
Patients must be age 18 years or older. There is no upper age limit.
Patients must have a probable diagnosis of epilepsy.
Participants must be age 18 years or older. There is no upper age limit.
Participants must be able to provide informed consent for themselves.

Exclusion

Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study
Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure)
Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study
Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure)

What this trial measures

  • Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with memory.Evaluated for each patient during monitoring period of approximately 2 weeks.

    Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving memory. The researchers will use the information to further the understanding of the exact location of cognitive functions.

  • Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with language.Evaluated for each patient during monitoring period of approximately 2 weeks.

    Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving language. The researchers will use the information to further the understanding of the exact location of cognitive functions.

  • Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with emotions.Evaluated for each patient during monitoring period of approximately 2 weeks.

    Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving emotions. The researchers will use the information to further the understanding of the exact location of cognitive functions.

  • Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with movement.Evaluated for each patient during monitoring period of approximately 2 weeks.

    Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving movement. The researchers will use the information to further the understanding of the exact location of cognitive functions.

  • Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with attention and executive function.Evaluated for each patient during monitoring period of approximately 2 weeks.

    Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving attention and executive function. The researchers will use the information to further the understanding of the exact location of cognitive functions.

  • Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with sound perception.Evaluated for each patient during monitoring period of approximately 2 weeks.

    Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving sound perception. The researchers will use the information to further the understanding of the exact location of cognitive functions.