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NCT05530356

Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study

Enrolling by Invitation
Not specifiedAges 12–26Observational
University of Colorado, Denver
~100 participants
Updated 2022-11-02 on ClinicalTrials.gov
What's tested:Aminohippurate Sodium Inj 20%Iohexol Inj 300 MG/MLDextran 40Renal BiopsyPositron Emission Tomography

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effective Renal Plasma Flow (ERPF)
Measured over 4 Hours
+13 more outcomes measured

Conditions

Type 2 Diabetes
Diabetes Type 2
Diabetic Nephropathies
Nephropathy
Obesity
Adolescent Obesity
Diabetic Kidney Disease

Explore related trials

ObesityType 2 Diabetes Mellitus

Where it's being run

1 sites across 1 states
Colorado1

Study leadership

  • Petter Bjornstad, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Colorado

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Obese youth with and without Type 2 Diabetes + lean controls who were previously enrolled in the Renal HEIR Study
Participants who will undergo a PET Scan: ≥ 18 years

Exclusion

Anemia
Seafood, iodine, or penicillin allergy
Pregnancy
MRI Scanning contraindications (claustrophobia, implantable devices, \>550 lbs)
History of bleeding or clotting disorders, thrombocytopenia, warfarin and/or heparin use
Taking sulfonamides, procaine, thiazolsulfone or probenecid

What this trial measures

  • Effective Renal Plasma Flow (ERPF)4 Hours

    Measured by PAH clearance

  • Glomerular Filtration Rate4 Hours

    Measured by Iohexol Clearance

  • Glomerular Size Selectivity4 hours

    Measured by Dextran sieving

  • Renal Oxygen Availability1 hour

    Measured by functional kidney MRI

  • Renal Perfusion1 hour

    Measured by functional kidney MRI + PET Scan

  • 11-C Acetate Tracer Uptake1 Hour

    Measured by PET Scan

  • Renal Oxidative Metabolism1 Hour

    Measured by PET Scan

  • Blood Volume Fraction1 Hour

    Measured by PET Scan

  • Glomerular Basement Membrane Width1 Hour

    Measured by Renal Biopsy

  • Mesangial Expansion1 Hour

    Measured by Renal Biopsy

  • Interstitial Fibrosis1 Hour

    Measured by Renal Biopsy

  • Renal Arteriosclerosis1 Hour

    Measured by Renal Biopsy

  • Spatial Transcriptomics1 Hour

    Measured by Renal Biopsy

  • Spatial Metabolomics1 Hour

    Measured by Renal Biopsy