MAD Study of IA-14069 for Rheumatoid Arthritis

This study is testing a new oral medicine called IA-14069. Researchers want to learn about its safety, how much of it stays in your body (pharmacokinetics), and what effects it has (pharmacodynamics). The study includes healthy volunteers and people with rheumatoid arthritis (RA) who are already taking methotrexate. Some participants will receive IA-14069, others will receive a placebo (an inactive substance), and some will receive methotrexate. The main goal is to track any side effects and how severe they are. The study plans to enroll 75 people. The current recruitment status is unclear.

Study design
This study is testing different doses of IA-14069 in healthy individuals and those with rheumatoid arthritis. It plans to include 75 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main safety information will be collected for up to 35 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05533372

MAD Study of IA-14069

Completed
PHASE1Ages 18–70InterventionalTreatment
ILAb Co., Ltd.
~78 participants
Updated 2026-08-19 on ClinicalTrials.gov
What's tested:IA-14069PlaceboMethotrexate

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidnece and severity of adverse events
Measured over up to Day 35
Healthy
Rheumatoid Arthritis
1 sites across 1 states
Kansas1

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

at least 6 swollen and 6 tender joints (based on 66/68 joint count), and
CRP ≥ ULN or ESR ≥ ULN
  • Incidnece and severity of adverse eventsup to Day 35

    Incidence and severity of adverse events (AEs) and serious AEs, including clinical laboratory values, vital signs, 12-lead electrocardiograms, and physical examination; changes from baseline.